Study type: Medical/biological study (experimental study)

Heat shock protein induction in fetal mouse brain as a measure of stress after whole of gestation exposure to mobile telephony radiofrequency fields. med./bio.

Published in: Pathology 2009; 41 (3): 276-279

Aim of study (acc. to author)

To study whether whole of gestation exposure of fetal mouse brain to mobile phone radiofrequency fields produces a stress response detectable by induction of heat shock proteins.

Background/further details

Pregnant mice (n=10) were exposed and prior to parturition on day 19, fetal brains (n=10, one fetal brain of each litter) were collected.
Positive controls were performed (thermal stress).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: 60 min/day from day 1 to day 19 of gestation

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration 60 min/day from day 1 to day 19 of gestation
Modulation
Modulation type pulsed
Pulse width 0.6 ms
Repetition frequency 217 Hz
Exposure setup
Exposure source
Setup mice placed in perspex tubes radially around the dipole antenna
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 4 W/kg - - whole body -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

There was no induction of HSP32 or HSP70 in any brains, while HSP25 expression was limited to two brainstem nuclei and occured consistenly in exposed and non-exposed brains.
In conclusion, using HSP as oxidative stress marker, the data showed that whole gestation exposure of fetal mouse brains to mobile phone radiofrequency fields did not produce any stress response.

Study character:

Study funded by

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