Study type: Medical/biological study (experimental study)

Continuous exposure to 900MHz GSM-modulated EMF alters morphological maturation of neural cells med./bio.

Published in: Neurosci Lett 2009; 455 (3): 173-177

Aim of study (acc. to author)

To study the effects of radiofrequency electromagnetic field exposure on neuronal phenotype maturation in two different in vitro models: murine primary cortical neurons (of rat) and murine cholinergic SN56 cell line.



Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: 1, 2 or 3 days for SN56 cell line; 1 to 6 days for cortical neurons

Exposure 1

Main characteristics
Frequency 900 MHz
Exposure duration 1, 2 or 3 days for SN56 cell line; 1 to 6 days for cortical neurons
Exposure setup
Exposure source
Setup couple of 14 cm wide TEM cells that produce a transverse electromagnetic field
Measurand Value Type Method Mass Remarks
SAR 1 W/kg - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The data showed that radiofrequency electromagnetic field exposure reduced the number of neurites generated by both cell systems, and this alteration correlates to increased gene expression of beta-thymosin. Gene expression of c-Fos and c-Jun was not affected by exposure. Additionally, neither neurite length nor branching was affected by exposure.
The alteration of beta-thymosin expression by radiofrequency exposure could be a direct or an indirect effect of the irradiation. Further studies are needed (also by means of other exposure schedules) to verify the effects described and to find out the molecular mediators and pathways modifying neural cell phenotype.

Study character:

Study funded by

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