研究のタイプ: 医学/生物学の研究 (experimental study)

[ミリ波照射は骨髄間質細胞から神経表現型細胞への分化を促進する] med./bio.

Millimeter-wave exposure promotes the differentiation of bone marrow stromal cells into cells with a neural phenotype.

掲載誌: J Huazhong Univ Sci Technolog Med Sci 2009; 29 (4): 409-412

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研究目的(著者による)

The study investigated the ability of millimeter waves to promote the differentiation of rat primary bone marrow stromal cells into cells with a neural phenotype, in an attempt to provide experimental basis for the future clinical application.

詳細情報

At cell passage 3, the cells were treated by beta-mercaptoethanol (to induce cell differentiation) alone or in combination with millimeter waves.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 36.11 GHz
ばく露時間: 10 minutes, three times at an interval of 2 h

General information

cells induced by i) beta-mercaptoethanol (BME) ii) BME + millimeter waves iii) control group

ばく露1

主たる特性
周波数 36.11 GHz
タイプ
  • electromagnetic field
ばく露時間 10 minutes, three times at an interval of 2 h
ばく露装置
ばく露の発生源/構造
  • millimeter wave radiator
ばく露装置の詳細 culture plate placed under the radiator in a thermotank at 37 °C
パラメータ
測定量 種別 Method Mass 備考
電力密度 10 mW/cm² - 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The untreated bone marrow stromal cells predominately expressed nucleostemin (a marker protein of stem cells prior to differentiation). After treatment by beta-mercaptoethanol and millimeter waves, the cells exhibited a dramatic decrease in nucleostemin expression and increase in neuron-specific enolase expression (a marker protein for neurons). The differentiation rate of the cells treated with beta-mercaptoethanol and millimeter wave exposure in combination was significantly higher than that of the cells treated with beta-mercaptoethanol alone.
The authors conclude that millimeter wave exposure enhanced the inducing effect of beta-mercaptoethanol on the differentiation of bone marrow stromal cells into cells with a neural phenotype.

研究の種別:

研究助成

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