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Medical/biological study (experimental study)

Mobile Phone Radiation Does Not Induce Pro-apoptosis Effects in Human Spermatozoa.

Published in: Radiat Res 2010; 174 (2): 169-176

Aim of study (acc. to author)

To study the effect of a one hour exposure to 900 MHz GSM mobile phone irradiation on the induction of pro-apoptosis events in human spermatozoa.
Background/further details: Semen samples were collected from healthy, nonsmoking donors (n=12) and examined at different times after exposure (immediately, after 2 h, and after 24 h).
Phosphatidylserine (PS) is a key phospholipid component of eucaryotic cell membrane and found almost exclusively on inner leaflet of the plasma membrane lipid bilayer in normal healthy cells. PS externalization is an important physiological signal (for example, in the apoptotic process).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 60 min.
Exposure 1
Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 60 min.
Modulation
Modulation type pulsed
Pulse width 577 ms
Additional info GSM like signal repetition rate: 4.615 ms
Exposure setup
Exposure source
Setup high-Q waveguide resonator in TE10 mode positioned inside a humidified incubator; cells placed inside the waveguide
Parameters
Measurand Value Type Method Mass Remarks
SAR 2 W/kg - measured and calculated - -
SAR 5.7 W/kg - measured and calculated - -
Reference articles
  • Falzone N et al. (2008): In vitro effect of pulsed 900 MHz GSM radiation on mitochondrial membrane potential and motility of human spermatozoa.
  • Leszczynski D et al. (2002): Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: Molecular mechanism for cancer- and blood-brain barrier-related effects.

Methods Endpoint/measurement parameters/methodology

Investigated material:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Mobile phone exposure had no statistically significant effect on any of the parameters studied. The data suggest that the impairment of male fertility reported in some previous studies (see "related articles") was not caused by the induction of apoptosis in spermatozoa.
Study character:

Study funded by

  • STUK (Radiation and Nuclear Safety Authority), Helsinki, Finland
  • National Research Foundation (NRF), Pretoria, South Africa
  • South African Bureau of Standards (SABS)

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