Study type: Medical/biological study (experimental study)

Does 900 MHz GSM Mobile Phone Exposure Affect Rat Brain? med./bio.

Published in: Electromagn Biol Med 2004; 23 (3): 201-214

Aim of study (acc. to author)

To study the effects of cell phone exposure on the fatty acid composition in phospholipids, malondialdehyde concentration, p53 immune reactivity and histological structure of the rat brain.

Background/further details

It is suggested that p53 immune reactivity may be related to the change of fatty acid composition in phospholipids. The loss of p53 appears to sensitize cells to fatty acid synthase inhibitors, and raises the possibility that these agents may be clinically useful against malignancies.
Malondialdehyde is a marker for lipid peroxidation, free radical damage, and oxidative stress. Lipid peroxidation may induce p53 immune reactivity.



Exposure Parameters
Exposure 1: 890–915 MHz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 20 min/day for 1 month

Exposure 1

Main characteristics
Frequency 890–915 MHz
Exposure duration repeated daily exposure, 20 min/day for 1 month
Modulation type pulsed
Repetition frequency 217 Hz
Additional info

DTX (discontinuous transmission mode) was activated. The phones were in speech condition sending a tape of human speech to the base station.

Exposure setup
Exposure source
Distance between exposed object and exposure source 0.5 cm
Chamber The rats were confined in Plexiglas cages (20 cm x 10.5 cm x 10 cm) with ventilation holes, and the cellular phones were placed 0.5 cm under the cages.
Setup Exposure began after the rats had selected a fixed location and settled into a prone position. The feed point of the antenna was placed under the cage against the brain.
Additional info For sham exposure, the setup was identical, except that the phone was switched off.
Measurand Value Type Method Mass Remarks
power 2 W peak value - - -
power 250 mW mean - - -
electric field strength 13.59 V/m mean measured - -
power density 0.047 mW/cm² mean measured - -
SAR 3.13 W/kg effective value calculated 1 g -
SAR 0.52 W/kg effective value measured and calculated whole body 0.29-0.87 W/kg

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Histological alteration and changes in brain phospholipid fatty acids composition were not found in the brains. p53 immune reactivity was not affected by cell phone exposure. Malondialdehyde concentration in exposed brains was significantly higher than in sham-exposed brains. The alteration in malondialdehyde does not appear sufficient to induce histological changes in brain tissue.

Study character:

Study funded by

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