Study type: Medical/biological study (experimental study)

Effects of Electromagnetic Radiation Use on Oxidant/Antioxidant Status and DNA Turn-over Enzyme Activities in Erythrocytes and Heart, Kidney, Liver, and Ovary Tissues From Rats: Possible Protective Role of Vitamin C. med./bio.

Published in: Toxicol Mech Methods 2008; 18 (9): 679-83

Aim of study (acc. to author)

To examine the effects of exposure to a 900 MHz electromagnetic field on oxidative processes in blood and several organs from rats as well as the possible protective effect of vitamin C.

Background/further details

Forty female rats were subjected to the following groups (n=10 per group): 1) control group, 2) vitamin C (250 mg/kg body weight/day, orally), 3) exposure and 4) exposure + vitamin C.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: 4 times a day for 10 minutes in speak mode for 4 weeks (otherwise in standby mode)
  • SAR: 1.2 W/kg

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration 4 times a day for 10 minutes in speak mode for 4 weeks (otherwise in standby mode)
Exposure setup
Exposure source
Distance between exposed object and exposure source 10 cm
Chamber rats were group caged
Setup mobile phone was oriented just above the cages
Additional info control group (group 1) and vitamin C group (group 2) were kept in another room
Parameters
Measurand Value Type Method Mass Remarks
SAR 1.2 W/kg - unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Remark EMF-Portal: If not stated otherwise, results were taken from the running text ("results" section) because tables are incomplete (parameters for liver are missing).
In erythrocytes, the lipid peroxidation and the enzyme activities of xanthine oxidase and glutathione peroxidase were significantly increased in exposed rats (group 3) when compared to the control group (group 1).
In heart tissue, the lipid peroxidation, the enzyme activities of the xanthine oxidase and adenosine deaminase were significantly decreased in the exposure group compared to the control group.
In kidney tissue, the lipid peroxidation and the enzyme activity of catalase were significantly increased in exposed rats compared to those from the control group while the enzyme activities of xanthine oxidase and adenosine deaminase were significantly decreased.
In ovary tissue, only xanthine oxidase was significantly lower in the exposure groups than in the control group (remark EMF-Portal: information about significance was taken from table).
In liver tissue, no significant differences were found between the exposure group and the control group.
Remark EMF-Portal: There are no results in the running text for groups with were given vitamin C (group 2 and group 4). Tables show several significant differences for the vitamin C group (group 2) compared to the exposure group plus vitamin C (group 4) as well as significant differences between the exposure group (group 3) and the exposure group plus vitamin C. However, these results are scarcely mentioned and discussed by the authors.
The authors conclude that exposure to a 900 MHz electromagnetic field could cause oxidative stress mainly in the erythrocytes and the kidney tissue from rats.

Study character:

Study funded by

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