研究のタイプ: 医学/生物学の研究 (experimental study)

Effects of Electromagnetic Radiation Use on Oxidant/Antioxidant Status and DNA Turn-over Enzyme Activities in Erythrocytes and Heart, Kidney, Liver, and Ovary Tissues From Rats: Possible Protective Role of Vitamin C. med./bio.

掲載誌: Toxicol Mech Methods 2008; 18 (9): 679-83

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研究目的(著者による)

To examine the effects of exposure to a 900 MHz electromagnetic field on oxidative processes in blood and several organs from rats as well as the possible protective effect of vitamin C.

詳細情報

Forty female rats were subjected to the following groups (n=10 per group): 1) control group, 2) vitamin C (250 mg/kg body weight/day, orally), 3) exposure and 4) exposure + vitamin C.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: 4 times a day for 10 minutes in speak mode for 4 weeks (otherwise in standby mode)
  • SAR: 1.2 W/kg

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 4 times a day for 10 minutes in speak mode for 4 weeks (otherwise in standby mode)
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
  • Ericsson GH 688
Distance between exposed object and exposure source 10 cm
チャンバの詳細 rats were group caged
ばく露装置の詳細 mobile phone was oriented just above the cages
Additional information control group (group 1) and vitamin C group (group 2) were kept in another room
パラメータ
測定量 種別 Method Mass 備考
SAR 1.2 W/kg - 指定なし - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Remark EMF-Portal: If not stated otherwise, results were taken from the running text ("results" section) because tables are incomplete (parameters for liver are missing).
In erythrocytes, the lipid peroxidation and the enzyme activities of xanthine oxidase and glutathione peroxidase were significantly increased in exposed rats (group 3) when compared to the control group (group 1).
In heart tissue, the lipid peroxidation, the enzyme activities of the xanthine oxidase and adenosine deaminase were significantly decreased in the exposure group compared to the control group.
In kidney tissue, the lipid peroxidation and the enzyme activity of catalase were significantly increased in exposed rats compared to those from the control group while the enzyme activities of xanthine oxidase and adenosine deaminase were significantly decreased.
In ovary tissue, only xanthine oxidase was significantly lower in the exposure groups than in the control group (remark EMF-Portal: information about significance was taken from table).
In liver tissue, no significant differences were found between the exposure group and the control group.
Remark EMF-Portal: There are no results in the running text for groups with were given vitamin C (group 2 and group 4). Tables show several significant differences for the vitamin C group (group 2) compared to the exposure group plus vitamin C (group 4) as well as significant differences between the exposure group (group 3) and the exposure group plus vitamin C. However, these results are scarcely mentioned and discussed by the authors.
The authors conclude that exposure to a 900 MHz electromagnetic field could cause oxidative stress mainly in the erythrocytes and the kidney tissue from rats.

研究の種別:

研究助成

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