Study type: Medical/biological study (experimental study)

Cytogenetic Studies in Human Cells Exposed In Vitro to GSM-900 MHz Radiofrequency Radiation Using R-Banded Karyotyping med./bio.

Published in: Radiat Res 2010; 174 (6): 712-718

Aim of study (acc. to author)

To study whether exposure to radiofrequency irradiation similar to that emitted by mobile phones (GSM) induces genotoxic effects in cultured human cells.

Background/further details

R-banded karyotyping was used, a method to evalutae both structural and numerical chromosome aberrations (i.e. chromosome mutations and genome mutations).
The genotoxic effect was assessed immediately or 24 h after exposure using four different samples (of four different donors). 100 metaphase cells were analyzed per assay. Positive controls were provided by using bleomycin (15 µM for 2 h).



Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 24 hr
  • SAR: 0.25 W/kg spatial average
  • SAR: 2 W/kg peak value

Exposure 1

Main characteristics
Frequency 900 MHz
Exposure duration continuous for 24 hr
Modulation type pulsed
Pulse width 0.577 ms
Repetition frequency 217 Hz
Exposure setup
Exposure source
Setup eight sample holders consisting of a 35 mm petri dish inside a 50 mm petri dish placed in a box with absorbing walls; the box was placed inside a 15 cm x 15 cm x 2.9 cm temperature-controlled wire patch cell inside an incubator
Sham exposure A sham exposure was conducted.
Measurand Value Type Method Mass Remarks
SAR 0.25 W/kg spatial average measured and calculated - -
SAR 2 W/kg peak value measured and calculated - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data did not show any direct cytogenetic effects of GSM mobile phone exposure either immediately or 24 h after exposure compared with sham exposed control cells.

Study character:

Study funded by

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