研究のタイプ: 医学／生物学の研究 (experimental study)

[電磁界ばく露した鼻粘膜および洞粘膜における一酸化窒素レベル] med./bio.

Nitric oxide level in the nasal and sinus mucosa after exposure to electromagnetic field

著者: Yariktas M, Doner F, Özgüner F, Gokalp O, Dogru H, Delibas N
掲載誌: Otolaryngol Head Neck Surg 2005; 132 (5): 713-716
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この研究は、無線周波電磁界（EMF）ばく露を受けたラットの鼻腔および副鼻腔の粘膜における一酸化窒素（NO）レベルの変化を調べた。オスのSprague-Dawleyラット30匹を無作為に３群に分けた。EMFばく露群（n = 10）、メラトニン経口投与＋EMFばく露群（n = 10）および擬似ばく露対照群（n = 10）である。EMF（周波数900 MHzの連続波、平均電力密度1.04 mW/cm2）ばく露は、30分／日、5日／週で、２週間反復的に実施された。2週間の終わりに、ラットを屠殺し、鼻および副鼻腔の粘膜を摘出し、粘膜のNOを測定した。その結果、EMFばく露群の鼻および副鼻腔の粘膜のNOレベルは、対照群に比べ有意に高かった（P < 0.05）；一方、メラトニン経口投与＋EMFばく露群と擬似ばく露対照群との間にNOレベルの有意差はなかった（P > 0.05）、と報告している。

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研究目的（著者による）

To investigate the changes in nitric oxide level in the nasal and paranasal sinus mucosa after exposure to radiofrequency electromagnetic fields (900 MHz).

詳細情報

Nitric oxide plays an important role in many physiologic processes in the body including vasoregulation, hemostasis, neurotransmission, respiration and immune defense. High nitric oxide levels were found in paranasal sinuses and it was thought that a decreased concentration of nitric oxide might contribute to the pathogenesis of sinusitis.
The rats were randomly grouped: group 1: EMF exposure; group 2: EMF and melatonin application; group 3: control group.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: repeated daily exposure, 30 min/day, 5 days/week for 2 weeks

General information

Animals were randomly allocated to three groups receiving the following treatment: EMF exposure, EMF exposure and oral melatonin, and sham exposure (control group).

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure, 30 min/day, 5 days/week for 2 weeks
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
チャンバの詳細 The exposure system consisted of a ventilated plastic tube cage (length 12 cm; diameter 5.5 cm) and a half-wave dipole antenna.
ばく露装置の詳細 The whole bodies of the rats were positioned in close contact above the antenna (near field).
Additional information Before the EMF exposure, animals were anesthetized with pentobarbital Na. Oral melatonin (10 mg/kg) was given with water daily following the EMF exposure. Control rats were also placed in the tube, but without exposure to EMF.
パラメータ
測定量 値 種別 Method Mass 備考
電力 2 W peak - - -
電力密度 1.04 mW/cm² mean 測定値 - -
測定および計算の詳細

Power density was measured using an EMF meter. Differentiation of power density according to distance along the half-wave dipole antenna was verified.

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 感覚器
  • nose
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Exposure to EMF released by mobile phones (900 MHz) significantly increased the nitric oxide levels of nasal and paranasal sinus mucosa. However, there was no statistically significant difference between group 2 (EMF and melatonin) and the control group regarding nitric oxide output. Increased nitric oxide levels may act as a defense mechanism and presumably related to tissue damage. In addition, melatonin may have beneficial effect to prevent these changes in the mucosa.

研究の種別:

研究助成

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