この研究は、先行研究で報告されている知見（超伝導磁石の7 T以上の静磁界へのばく露によるラットの行動への影響）をより制御された条件下で確認するために、20 T常伝導磁石で作成された直径189 mmのボア内で、ラットに4〜19.4 Tの静磁界ばく露を与えた。ボア内の磁界は、-19.4〜19.4 Tの範囲で任意に変えることができた。その結果、4 T以上のばく露後に、立ち上がり行動が抑制された；7 T以上のばく露後に、旋回行動が観察された；条件付けられた味覚嫌悪は14 T以上のばく露後に獲得された；影響は磁界の方向に依存しており、+14 Tへのばく露は反時計回りの旋回を引き起こし、-14 Tへのばく露は時計回りの旋回を引き起こした；磁界の方向がラットの体軸と垂直な場合、平行な場合に比べ、行動反応が減少した；単一の常伝導磁石内で得られたこのような知見は、複数の超伝導磁石を使用した先行研究の知見を確認し、さらに拡張したものとなった、と報告している。
The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →
In order to confirm the data of previous studies (see publication 145 and publication 9725) under more controlled conditions, rats were exposed to static magnetic fields of 4 to 19.4 Tesla in a 189 mm bore, 20 Tesla resistive magnet.
By using a resistive magnet (instead of superconducting NMR magnets as in the previous studies), field strengths could be arbitrary varied from -19.4 to 19.4 Tesla.
| 周波数 |
|
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 30 min |
| ばく露の発生源／構造 |
|
|---|---|
| ばく露装置の詳細 | Rats were placed individually and immobilized into a Plexiglas restraining tube (56 mm inner diameter, 64 mm outer diameter). Four tubes were suspended vertically in the magnet so that the magnetic field lines were parallel. |
| Sham exposure | A sham exposure was conducted. |
| Additional information | Rats were also exposed (14 T) or sham exposed with the magnetic field lines running parallel to the dorsal ventral axis by restraining the rats in a horizontal position in the core of the magnet. |
| 周波数 |
|
|---|---|
| タイプ |
|
| ばく露時間 | repeated daily exposure, 30 min/day for 3 consecutive days |
| ばく露の発生源／構造 |
|
|---|---|
| Additional information | Exposure to reverse polarity was achieved by positioning the heads of the rats face down, hence towards the negative pole. |
Rearing (one or both forepaws on the side of the cage) was suppressed after exposure to 4 Tesla and above; circling was found after 7 Tesla and above. Conditioned taste aversion (see publication 145) was acquired after 14 Tesla and above.
The effects were dependent on orientation in the field: Exposure to +14 Tesla induced counter-clockwise circling, while exposure to -14 Tesla induced clockwise circling. Exposure with the rostral-caudal axis of the animal perpendicular to the magnetic field produced an attenuated behavioral response compared to exposure with the rostral-caudal axis parallel to the field.
These findings in a single resistive magnet confirm and extend the authors' earlier results using multiple superconducting magnets. The effects of exposure to 4 Tesla are clinically relevant, as 4 Tesla magnetic fields are commonly used in functional MRI assays.
このウェブサイトはクッキー（Cookies）を使って、最善のブラウジングエクスペリエンスを提供しています。あなたがこのウェブサイトを継続して使用することで、私たちがクッキーを使用することを許可することになります。
