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To study the effects of mobile phones electromagnetic fields or its pure, low frequency pulsed electric field component on endocytosis and further to elucidate the molecular mechanisms of GSM-induced increase of endocytosis rate found in a previous study (publication 11586).
Under controlled electromagnetic field or pulsed electric field exposure cells were incubated with drugs (Filipin, ethanol, chlorpromazine) inhibiting the endocytosis mediated by clathrin-coated vesicles or by caveolin-coated vesicles. In specialized literature, several molecular mechanisms for endocytosis are described: clathrin-dependent endocytosis, caveolin-mediated endocytosis, macro-pinocytosis, and clathrin- and caveolin-independent endocytosis
Lucifer Yellow uptake increased under exposure to GSM electromagnetic fields. Chlorpromazine (inhibitor of the clathrin-mediated pathway) and ethanol (inhibitor of receptor-mediated endocytosis/clathrin-dependent pathway), but not Filipin (inhibitor of the caveolin-mediated pathway), inhibited this increase. The data show that the mechanism affected by the GSM electromagnetic field involves vesicles that detach from the cell membrane, mainly by clathrin-coated vesicles.