研究のタイプ: 治療に関する研究 (experimental study)

[治療抵抗性抑うつ患者での経頭蓋低電圧パルス電磁界療法] med. app.

Transcranial low voltage pulsed electromagnetic fields in patients with treatment-resistant depression.

掲載誌: Biol Psychiatry 2010; 68 (2): 163-169

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研究目的(著者による)

To evaluate the antidepressant effect of a new treatment principle using low-intensity transcranially applied pulsed electromagnetic fields (T-PEMF) in combination with antidepressants in patients with treatment-resistant depression.

詳細情報

The psychopharmacological treatment (antidepressants, mood stabilizers, antipsychotics, tranquilizers, and hypnotics) was unchanged during the previous four weeks (before treatment) and was maintained on the same dosage throughout the study. In total, 50 patients were included (from June 2006 to February 2009; treatment group n=25, sham exposure group n=25).
See here for additional information.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 55 Hz
Modulation type: pulsed
ばく露時間: 5 days/week for 5 weeks

ばく露1

主たる特性
周波数 55 Hz
タイプ
  • magnetic field
波形
  • rectangular
ばく露時間 5 days/week for 5 weeks
Modulation
Modulation type pulsed
Pulse width 3 ms
Repetition frequency 55 Hz
Pulse type biphasic
Additional information

pulses with a 12 ms pause between them

ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 plastic treatment helmet with 7 coils: two in the anterior and posterior temporal region on both sides, one in the upper parietal region on both sides and one in the center of the lower occipital region
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 2.2 mV/cm - 測定値 - at a distance of 0.5 cm from the coil
電界強度 30 µV/cm - 測定値 - at a distance of 10 cm from the coil
磁束密度 1.9 mT maximum 計算値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中

研究の主なアウトカム(著者による)

Patients exposed to active transcranially applied pulsed electromagnetic fields showed a clinically and statistically significant better outcome than patients treated with sham exposure condition, with an onset of action within the first weeks of therapy. Treatment-emergent side effects were few and mild.

研究の種別:

研究助成

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