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To evaluate the antidepressant effect of a new treatment principle using low-intensity transcranially applied pulsed electromagnetic fields (T-PEMF) in combination with antidepressants in patients with treatment-resistant depression.
The psychopharmacological treatment (antidepressants, mood stabilizers, antipsychotics, tranquilizers, and hypnotics) was unchanged during the previous four weeks (before treatment) and was maintained on the same dosage throughout the study. In total, 50 patients were included (from June 2006 to February 2009; treatment group n=25, sham exposure group n=25).
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|ばく露時間||5 days/week for 5 weeks|
|Pulse width||3 ms|
|Repetition frequency||55 Hz|
pulses with a 12 ms pause between them
|ばく露装置の詳細||plastic treatment helmet with 7 coils: two in the anterior and posterior temporal region on both sides, one in the upper parietal region on both sides and one in the center of the lower occipital region|
|Sham exposure||A sham exposure was conducted.|
Patients exposed to active transcranially applied pulsed electromagnetic fields showed a clinically and statistically significant better outcome than patients treated with sham exposure condition, with an onset of action within the first weeks of therapy. Treatment-emergent side effects were few and mild.