研究のタイプ: 医学/生物学の研究 (experimental study)

[発達中のラットのエネルギーバランスに対する無線周波電磁界への慢性ばく露の影響] med./bio.

Effects of chronic exposure to radiofrequency electromagnetic fields on energy balance in developing rats.

掲載誌: Environ Sci Pollut Res Int 2013; 20 (5): 2735-2746

この研究は、身体のエネルギー・ホメオスタシスに関与する主な機能(摂食行動睡眠及び体温調節プロセス)に対する無線周波RF電磁界(900MHz、1V/m)への慢性ばく露の影響を調べた動物実験である。13匹の幼若の雄のWistarラットを連続的なRFに5週間、気温24℃でばく露し、11匹の非ばく露群と比較した。ばく露6週目の開始時、気温24℃及び31℃で機能を記録した。その結果、RFばく露群ではREM睡眠エピソードの頻度が高まり、これは気温には依存しなかった;その他の複数の睡眠パラメータへのRFの影響は気温に依存していた;RFばく露群では全ての睡眠ステージで対照群よりも尾部皮下温が有意に低かった;RFばく露は日中の食物摂取量も増加させた;観察されたRFばく露の影響のほとんどは気温に依存していた、と報告している。

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研究目的(著者による)

To study the effects of a chronic radiofrequency electromagnetic field on the main functions of body energy homeostasis (food intake, sleep and thermoregulatory processes). Another aim was to analyze the impact of the vasodilatator Prazosin on the tail temperature.

詳細情報

Two experiments were performed. First, 13 juvenile male rats were exposed to a radiofrequency electromagnetic field for 5 weeks at 24°C and 31°C (remark EMF-Portal editor: duration of exposure at 31°C room temperature not clear) room temperature and compared to 11 unexposed rats. Sleep pattern and EEG power spectrum were analyzed as well as food intake. Additionally, the subcutaneous tail temperature and the cortical temperature were recorded for 10 exposed rats and for 9 control rats.
For the second experiment, Prazosin (inhibits the peripheral vasomotor tone) was injected into 5 exposed and 5 unexposed rats and the tail temperature was recorded.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: continuous for 23.5 h/day, 7 days/week for 5 weeks
  • 電界強度: 1 V/m
  • SAR: 0.3 mW/kg (for 3 weeks old rats)
  • SAR: 0.1 mW/kg (for 8 weeks old rats)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 continuous for 23.5 h/day, 7 days/week for 5 weeks
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • four broadband directional antennas
ばく露装置の詳細 rats housed in individual 32 cm x 35 cm x 20.5 cm plastic cages with metallic grids at the bottom; cages placed inside a 2.4 m x 2.43 m x 1.6 m air-conditioned, sound-proofed climatic chamber; four 23 cm x 14 cm x 5 cm broadband, directional, vertically polarized gain antennas positioned horizontally 80 cm above the rats' cages; distance between the antennas = 48 cm
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 1 V/m - - - -
SAR 0.3 mW/kg - 計算値 whole body for 3 weeks old rats
SAR 0.1 mW/kg - 計算値 whole body for 8 weeks old rats

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中

研究の主なアウトカム(著者による)

The frequency of REM sleep episodes was greater in the radiofrequency field exposed group than in the unexposed group, independently of the room temperature. At 31°C room temperature the exposed group showed a lower frequency of waking state and non-REM sleep episodes, compared with the control group, whereas at 24°C in exposed animals only the duration of waking states was lower than in control animals. Additionally, exposure to a radiofrequency field did not have a significant effect on the spectral power density of the EEG signal.
At 31°C room temperature, exposed animals had a significantly lower subcutaneous tail temperature than controls. No significant differences in the temperature of the tail were observed between exposed and unexposed animals at 24°C. Exposure did not appear to have a significant effect on the temperature of the cerebral cortex. After an injection of Prazosin, the temperature of the tail increased in exposed rats, while the temperature of the tail did not change in the control group.
In general, food intake was less at 31°C room temperature than at 24°C. At 31°C, exposed rats consumed more food than unexposed rats. There was no such a difference between exposed and unexposed rats at 24°C.
The authors conclude that electromagnetic field exposure did not modify strongly the overall sleep pattern and increased the peripheral vasoconstriction which promoted heat storage and the food intake.

研究の種別:

研究助成

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