研究のタイプ: 医学／生物学の研究 (experimental study)

[ラットにおける無線周波放射によるハイパサーミアと2-メトキシエタノールの催奇形性の相互作用] med./bio.

Interactions of radiofrequency radiation-induced hyperthermia and 2-methoxyethanol teratogenicity in rats

著者: Nelson BK, Conover DL, Krieg Jr EF, Snyder DL, Edwards RM
掲載誌: Bioelectromagnetics 1997; 18 (5): 349-359
RISフォーマットで参考文献をダウンロード

この研究は、妊娠13日目のラットを用いて、RF照射による高体温の程度と持続時間および投与されたメトキシエタノール（2ME：100mg / kg）の相互作用を調べた。RF照射による高体温の程度は、対照[38.5]、39.0、40.0、41.0℃で結腸温度を維持する程度、持続時間は最大6時間まで変化させた。相互作用の用量反応パターンを特徴づけることに焦点を当て、最も低い相互作用レベルを決定することを目的とした。妊娠20日目の胎児で外形および骨格奇形の検査をした。その結果、結腸温41℃を1時間維持するのに十分なRF照射と2MEとの間に有意な相互作用が観察された；より長い持続時間であっても、これより低温では一貫した相互作用は見られなかった、と報告している。

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研究目的（著者による）

The authors demonstrated in previous studies that combined exposure to radiofrequency irradiation (10 MHz) and the industrial solvent, 2-methoxyethanol, produces enhanced teratogenicity in rats (see publication 3522 and publication 3519).
The purpose of the present study was to determine the effects of varying the degree and duration of hyperthermia induced by radiofrequency irradiation (sufficient to maintain colonic temperatures at control [38.5], 39.0, 40.0, or 41.0°C for up to 6 h) and 2-methoxyethanol administered on gestation day 13 of rats.

詳細情報

Focusing on characterizing the dose-response pattern of interactions, this investigation seeks to determine the lowest interactive effect level.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 10 MHz
Modulation type: CW
ばく露時間: continuous for 2, 4 or 6 h
Target colonic temperature was set to 39°C
  • SAR: 7.9 W/kg mean (whole body) (applied initially to raise the temperature from 38.5°C to 39°C, 40°C or 41°C (20 min approximately))
  • SAR: 0.8 W/kg mean (whole body) (to 7.9 W/kg; SAR was adjusted to maintain the target temperature)
ばく露2: 10 MHz
Modulation type: CW
ばく露時間: continuous for 1, 2, 3 or 4 h
Target colonic temperature was set to 40°C
  • SAR: 7.9 W/kg mean (whole body) (same remark as in E1)
  • SAR: 0.8 W/kg mean (whole body) (same remark as in E1)
ばく露3: 10 MHz
Modulation type: CW
ばく露時間: continuous for 1 h
Target colonic temperature was set to 41°C
  • SAR: 7.9 W/kg mean (whole body) (same remark as in E1)
  • SAR: 0.8 W/kg mean (whole body) (same remark as in E1)

ばく露1

主たる特性
周波数 10 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 continuous for 2, 4 or 6 h
Additional information Target colonic temperature was set to 39°C
Additional information Target colonic temperature was set to 39°C.
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • Parallel plate electric field applicator
チャンバの詳細 Near field synthesizers enclosed within copper wire chambers housed in Forma 7010 or 74668 environmental chambers
ばく露装置の詳細 Rats placed in cylindrical Plexiglas holders with 12 mm holes which was placed on a Plexiglas table. The holders were designed to prevent the rat from changing its orientation. Each rat was oriented in its long axis for induced electric field to be parallel.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 7.9 W/kg mean 測定値および計算値 whole body applied initially to raise the temperature from 38.5°C to 39°C, 40°C or 41°C (20 min approximately)
SAR 0.8 W/kg mean 測定値および計算値 whole body to 7.9 W/kg; SAR was adjusted to maintain the target temperature
Additional parameter details

In the sham exposure chamber 60 Hz EF were 0.17 to 0.20 V/m and 60 Hz MF ranged from 0.05 to 0.18 µT.

ばく露2

主たる特性
周波数 10 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 continuous for 1, 2, 3 or 4 h
Additional information Target colonic temperature was set to 40°C
Additional information Target colonic temperature was set to 40°C.
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
パラメータ
測定量 値 種別 Method Mass 備考
SAR 7.9 W/kg mean 測定値および計算値 whole body same remark as in E1
SAR 0.8 W/kg mean 測定値および計算値 whole body same remark as in E1

ばく露3

主たる特性
周波数 10 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 continuous for 1 h
Additional information Target colonic temperature was set to 41°C
Additional information Target colonic temperature was set to 41°C.
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
パラメータ
測定量 値 種別 Method Mass 備考
SAR 7.9 W/kg mean 測定値および計算値 whole body same remark as in E1
SAR 0.8 W/kg mean 測定値および計算値 whole body same remark as in E1

Reference articles

  • Nelson BK et al. (1994): [ラットにおける無線周波放射および2-メトキシエタノールによる相互作用的な発生毒性]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

The findings are consistent with previous observations. Significant interactions were observed between 2-methoxyethanol and radiofrequency irradiation sufficient to maintain colonic temperatures at 41°C for 1 h, but no consistent interactions were revealed at lower temperatures even with longer durations. These findings indicate that combined exposure effects should be considered when developing both radiofrequency irradiation and chemical exposure guidelines.

研究の種別:

研究助成

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