研究のタイプ: 医学／生物学の研究 (experimental study)

[ラットの歯の発達および歯の元素濃度への出生前および後のWi-Fiばく露の影響：Wi-Fi (2.45GHz)と歯の元素濃度] med./bio.

Effects of Prenatal and Postnatal Exposure of Wi-Fi on Development of Teeth and Changes in Teeth Element Concentration in Rats : Wi-Fi (2.45 GHz) and Teeth Element Concentrations

著者: Ciftci ZZ, Kirzioglu Z, Naziroglu M, Ozmen O
掲載誌: Biol Trace Elem Res 2015; 163 (1-2): 193-201
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この研究は、ラットの歯の発達および歯の元素濃度に対する出生前および後のWi-Fi（2.45GHz）ばく露の影響を調べた。母ラットおよびその仔ラットを、ばく露群と擬似ばく露群に無作為に分け、妊娠期間（21日間）とその後の授乳期間（21日間）を通して、1日2時間のWi-Fi電磁界ばく露（擬似ばく露）を与えた。出生後7、14、21日目に、それぞれ両群から雄の仔ラット8匹を取りだして屠殺し、顎部の組織学的、免疫学的検査を行い、切歯を採集した。その結果、両群において、成長期の歯の周辺組織で、アポトーシスおよびカスパーゼ3は上昇したが、両群に有意差はなかった；歯の元素分析では、ばく露群で、鉄、ストロンチウムの濃度上昇、およびホウ素、銅、亜鉛の濃度低下が見られた､と報告している。

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研究目的（著者による）

The effects of a prenatal and postnatal exposure of rats to a 2.45 GHz electromagnetic field on the development and composition of teeth should be investigated.

詳細情報

24 pregnant rats were divided into two groups (n=12 each): an exposure group and a sham exposure group, which were (sham) exposed during gestation. After birth, their offspring was further (sham) exposed in two groups with n=24 animals, respectively. On the 7th, 14th, and 21st day after birth, n=8 offspring rats from each group were killed and examined, respectively.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: pulsed
ばく露時間: continuous for 2 h/day during gestation (21 days) and up to 21 after birth
  • SAR: 9 mW/kg (± 2 mW/kg; for the head)

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 2 h/day during gestation (21 days) and up to 21 after birth
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源／構造
チャンバの詳細 specific room with plastic furniture and walls completely covered with chromium-nickel sheets
ばく露装置の詳細 six rats were exposed simultaneously in ventilated cylindrical PVC restrainers; animals were placed with close contact to the antenna; exposure systems and procedures were kept in a Faraday cage, which had a shielding effectiveness of 100 dB
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 9 mW/kg - 測定値および計算値 - ± 2 mW/kg; for the head

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

The only significant differences between exposed and sham exposed animals were found in the elemental composition of the incisors after 21 days. The amounts of strontium and iron were significantly increased whereas boron, copper and zinc were significantly decreased in the exposure group compared to the sham exposure group.
The authors conclude that a prenatal and postnatal exposure of rats to a 2.45 GHz electromagnetic field has no effects on the development of teeth. However, changes in the chemical elemental composition of teeth with unknown consequences might be induced.

研究の種別:

研究助成

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