研究のタイプ: 医学／生物学の研究 (experimental study)

[歯周炎の治癒過程に対するパルス電磁界効果の研究用ヘルムホルツコイルの設計と製作：予備的な動物実験結果] med./bio.

Design and fabrication of Helmholtz coils to study the effects of pulsed electromagnetic fields on the healing process in periodontitis: preliminary animal results

著者: Haghnegahdar A, Khosrovpanah H, Andisheh-Tadbir A, Mortazavi G, Saeedi Moghadam M, Mortazavi S, Zamani A, Haghani M, Shojaei Fard M, Parsaei H, Koohi O
掲載誌: J Biomed Phys Eng 2014; 4 (3): 83-90
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この研究は，ラットへのパルス電磁界（PEMF：50Hz）ばく露を目的としたヘルムホルツコイル（コイル直径およびコイル間距離12.5cm、中心磁界97.6 μT）を製作したことを報告して、今後ラットの歯肉炎治癒へのPEMFの効果を調べる予定と述べている。

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研究目的（著者による）

The effects of an acute whole body exposure of rats to a 50 Hz magnetic field on the progress of periodontitis should be investigated.

詳細情報

Periodontitis is a bacteria-caused inflammation of the peridontitium, which gets largely irreversibly destroyed in the course of the disease. The therapeutic use of the magnetic field in the treatment of periodontitis should be estimated with this preliminary study. In each of 10 rats, experimental periodontitis was induced on the left side of the upper jaw. No periodontits was induced on the right side of the upper jaw and this side was used as the control.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
Modulation type: pulsed
ばく露時間: continuous for 4 h/day for 7 days
  • 磁束密度: 97.6 µT unspecified (at the center of the space between coils)

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 4 h/day for 7 days
Modulation
Modulation type pulsed
ばく露装置
ばく露の発生源／構造
チャンバの詳細 rats were immobilized during exposure by using standard Plexiglas restrainers
ばく露装置の詳細 two pairs of Helmholtz coils had an inner radius of 12.5 cm, an outer radius of 13.5 cm and consisted of 100 turns of 0.95 mm wire framed on Teflon, respectively; distance between coils was 12.5 cm; temperature was measured
パラメータ
測定量 値 種別 Method Mass 備考
磁束密度 97.6 µT unspecified 測定値 - at the center of the space between coils
Additional parameter details

peak voltage 2.1 V

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • teeth, gingiva
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム（著者による）

A significantly decreased gingiva inflammation and mobility of the animals' teeth was found in exposed animals (remark EMF-Portal: no data shown on reference or determination of this result).
The authors conclude that an acute whole body exposure of rats to a 50 Hz magnetic field might have a positive effect on the healing of periodontitis, what should be investigated further in subsequent studies.

研究の種別:

研究助成

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