研究のタイプ: 医学/生物学の研究 (experimental study)

[低レベルマイクロ波放射と中枢コリン作動系] med./bio.

Low-level microwave irradiation and central cholinergic systems.

掲載誌: Pharmacol Biochem Behav 1989; 33 (1): 131-138

この研究は、先行研究に引き続き、低レベルのパルス変調マイクロ波(2450MHz、パルス幅2マイクロ秒、500pps、全身平均SAR 0.6W / kg)の単回ばく露(45分間)および反復ばく露(1日20または45分間、毎日、10日間)が、中枢コリン作動系に与える影響を調べた。その結果、単回の急性ばく露の20分後に、前頭皮質海馬および視床下部におけるコリン取り込み活性の増加が観察された;10日間の反復ばく露(20分間)では、マイクロ波の影響に対する耐性が視床下部では観察されたが、前頭皮質および海馬では観察されなかった;さらに、麻酔性拮抗薬ナルトレキソンばく露前投与により、急性ばく露で観察された中枢コリン作動系への影響は阻害された、と報告している。また、別の一連の実験(20または45分間のばく露時間での10日間反復ばく露)で調べた、ムスカリン性コリン作動性受容体への影響についても報告している。

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研究目的(著者による)

To investigate the neurological effect of low-level microwave irradiation, and the biochemical and behavioral consequences of repeated exposure of rats.

詳細情報

In the first series of experiments the effects of acute exposure on choline uptake in four regions of the brain (striatum, frontal cortex, hippocampus, and hypothalamus) containing high amounts of cholinergic innervations were examined. In the second series of experiments it was studied whether the effects of acute (20-min) microwave exposure on central cholinergic activity could be blocked by pretreatment with narcotic antagonist naltrexone hydrochloride), since the authors have speculated that microwave irradiation is a stressor and some of their effects are mediated by endogenous opioids. Finally, the effects of microwave exposure on learning in the radial-arm maze were examined.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: pulsed
ばく露時間: 10 x 20 min or 45 min sessions
  • 電力密度: 10 W/m² mean (within the waveguide.)
  • SAR: 600 µW/g mean (whole body) (determined calorimetrically.)

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
偏波
  • circular
ばく露時間 10 x 20 min or 45 min sessions
Modulation
Modulation type pulsed
Pulse width 2 µs
Packets per second 1
Repetition frequency 500 Hz
ばく露装置
ばく露の発生源/構造
Additional information please see the reference article on detailed exposure set-up.
パラメータ
測定量 種別 Method Mass 備考
電力密度 10 W/m² mean 測定値 - within the waveguide.
SAR 600 µW/g mean 計算値 whole body determined calorimetrically.

Reference articles

  • Guy AW et al. (1979): [小動物のマイクロ波慢性ばく露に用いる円偏光2450 MHz導波管装置]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Increases in choline uptake activity in the frontal cortex, hippocampus, and hypothalamus were observed after 20 min of acute microwave exposure. Tolerance to the effect of microwaves developed in the hypothalamus, but not in the frontal cortex and hippocampus, of rats subjected to ten daily 20-min exposure sessions. Furthermore, the effects of acute microwave irradiation on central choline uptake could be blocked by pretreating the rats before radiation with the narcotic antagonist naltrexone.
Decreases in concentration of muscarinic receptors occured in the frontal cortex and hippocampus of animals subjected to ten 20-min microwave exposure sessions, whereas increase in receptor concentration occured in the hippocampus of animals exposed to ten 45-min sessions.
Radiation for 20 min before maze training had no significant effect on learning, but a significant treatment X training-session interaction was observed suggesting that the learning curves of the microwave- and sham-exposed animals are different. Retardation in learning was observed after 45 min of microwave exposure. The data showed significant treatment main effect and treatment X training-session interaction effects.

研究の種別:

研究助成