研究のタイプ: 医学/生物学の研究 (experimental study)

[マイクロ波にばく露したウサギの大脳皮質の徐波および棘波活動] med./bio.

Slow potentials and spike unit activity of the cerebral cortex of rabbits exposed to microwaves.

掲載誌: Bioelectromagnetics 1988; 9 (4): 337-345

この研究は、無麻酔のウサギの頭部領域に40mW / cm 2の電磁界強度波長12.5cmのマイクロ波ばく露を与え、脳活動への影響を調べた。その結果、脳電図において、徐波および紡錘波の数が増加した;試行の41〜52%において、 視覚野ニューロン発火頻度に変化が見られた;試行の61%において、光に対する 視覚野ニューロン誘発反応の増強が見られ、すべての試行の80%において、光駆動反応が促進された、と報告している。(参考)光駆動反応(driving response):周期的閃光刺激により、刺激サイクルと同一あるいは調和関係にあるサイクル数の波が後頭部優位に出現する。正常者においても出現する生理的反応である。

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研究目的(著者による)

To analyze the evoked activity and driving response in the cerebral cortex during EEG reactions and to determine if changes in the neuronal activity occur in response to microwaves.

詳細情報

Slow potentials and spike unit activity were investigated. The analysis involved consideration of 1) the background activity, 2) the evoked response to single light flashes, and 3) the evoked response to sequences of light flashes of increasing intensity or increasing frequency (driving response).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
Modulation type: CW
ばく露時間: 1 min/measurement
ばく露2:
Modulation type: CW
ばく露時間: 1 min

ばく露1

主たる特性
タイプ
  • electromagnetic field
波形
  • sinusoidal
ばく露時間 1 min/measurement
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • Cylindrical irradiating unit
Distance between exposed object and exposure source 0.1 m
ばく露装置の詳細 animals restrained in wooden frame, with the long axis of the animal parallel to the vector E.
Additional information In the control experiments the biopotential were registered under similar conditions, but without microwave exposure.
パラメータ
測定量 種別 Method Mass 備考
電力密度 400 W/m² unspecified 測定値 - -

ばく露2

主たる特性
タイプ
  • electromagnetic field
波形
  • sinusoidal
ばく露時間 1 min
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • LUCH-58 generator with cylindrical irradiating unit
Distance between exposed object and exposure source 0.1 m
ばく露装置の詳細 rabbits restrained in wooden frame
Additional information Exposure setup not described in detail. Type of antenna non-standard (ittem in corresponding field of data base thus not correct). Determination of power density unknown.
パラメータ
測定量 種別 Method Mass 備考
電力密度 400 W/m² unspecified 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

A 1-min microwave exposure of the animals head produced an EEG response by an increased number of spindle-shape firings and slow waves. These were accompanied by a change in pulse frequency of neurons, an increase in some cells and a decrease in other cells.
After microwave irradiation an enhancement of evoked responses was observed in the visual cortex neurons to single light flashes in 61% of the cases. The microwave fields facilitated the driving response to light flashes in 80% of cases. This was evidenced by a decreased threshold for obtaining evoked potentials and widening of the frequency range to which neurons were able to respond.
The evoked activity was a more sensitive indicator of the radiofrequency electromagnetic field effect than background activity. The reactivity alterations were more easily detected when using the driving response test than by using single stimuli.

研究の種別:

研究助成

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