研究のタイプ: 医学/生物学の研究 (experimental study)

[組織培養における細胞増殖に対する電磁界の影響] med./bio.

Effect of controlled electromagnetic radiation on the growth of cells in tissue culture.

掲載誌: J Surg Res 1979; 27 (1): 8-13

この研究は、多種多様な、哺乳動物細胞および細菌細胞に、厳密な温度制御下で、波長12 cm、周波数2.45GHz、電流120 mAのマイクロ波放射へのばく露を与えた。その結果、マイクロ波放射は、哺乳動物細胞の増殖に、独特の「非熱的」な阻害効果を持つように見えた;さまざまな細胞株は、ばく露に対して、それぞれ異なる感受性を示した;L60T細胞は、細胞周期のM期とG1期にのみマイクロ波ばく露の影響を受けやすかった、と報告している。

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研究目的(著者による)

To investigate the effects of 2450 MHz microwave exposure on the growth of different mammalian cell lines and six different bacterial strains.

詳細情報

Investigated mammalian cell lines were VX2, RT, L-929, and L60T.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
ばく露時間: 5 times for 1 min each
-

ばく露1

主たる特性
周波数 2.45 GHz
ばく露時間 5 times for 1 min each
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 Cells were exposed in scintillation vails which were supported by a polystyrene table which turns at a constant speed of 23 rpm.
パラメータ

No parameters are specified for this exposure.

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The growth of L-929 cells was significantly decreased by microwave exposure and microscopic analysis revealed lysis and cellular disruption.
The effects of microwave exposure in context with cell cycle was studied on L60T cells. No effects were observed on cells in S phase and G1 phase whereas growth of cells in mitosis phase as well as in G2 phase was decreased due to microwave exposure.
Preliminary experiments on VX2 and RT cell lines indicate that these cells are more sensitive to microwave exposure than the L-cell lines.
No alterations on the growth of the investigated six different bacterial strains (Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) were observed.

研究の種別:

研究助成

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