Study type: Medical/biological study (experimental study)

Individual responsiveness to induction of micronuclei in human lymphocytes after exposure in vitro to 1800 MHz microwave radiation. med./bio.

Published in: Mutat Res Genet Toxicol Environ Mutagen 2005; 582 (1-2): 42-52

Aim of study (acc. to author)

To assess the capability of microwaves to induce genotoxic effects.

Background/further details

Peripheral blood lymphocytes from nine different healthy donors were evaluated to investigate also the possible inter-individual response variability. Reproducibility was tested by repeating the experiment three months later.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,800 MHz
Modulation type: CW
Exposure duration: continuous for 60, 120, and 180 min

Exposure 1

Main characteristics
Frequency 1,800 MHz
Type
Exposure duration continuous for 60, 120, and 180 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup Three millilitres of whole blood were exposed at room temperature (21-22 °C). Sample tubes were placed in a supporting frame, made of anechoic material, at an aerial distance ensuring continuous field conditions.
Additional info Temperature variation was measured in water samples under the same experimental conditions of culture irradiation.
Parameters
Measurand Value Type Method Mass Remarks
power density 5 mW/cm² unspecified measured - -
power density 10 mW/cm² unspecified measured - -
power density 20 mW/cm² unspecified measured - -

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

It was shown that lymphocyte proliferation indices were significantly different among donors and between experiments, whereas the applied power density and the irradiation time did not have any effect on them.
Both spontaneous and induced micronuclei frequencies varied significantly among donors and between experiments. A statistically significant increase of micronuclei, although rather low, was revealed dependent on exposure time and applied power density. A considerable decrease in spontaneous and induced micronuclei frequencies was found in the second experiment.
The data show that microwaves are able to induce micronuclei in short-time exposures to medium power density fields. The data analysis highlights a wide inter-individual variability in the response, which was confirmed to be a characteristic reproducible trait by means of the second experiment.

Study character:

Study funded by

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