研究のタイプ: 医学/生物学の研究 (experimental study)

[血液脳関門に対する携帯電話放射の潜在的影響] med./bio.

Potential Impact of Simulated Mobile Phone Radiation on Blood-Brain Barrier.

掲載誌: Electromagn Biol Med 2005; 24 (3): 355-358

ラットを実験的に無機マンガンMn)と携帯電話放射ばく露させ、脳中のMNレベル変化などに影響をもたらすと考えられる相互作用を調べた。急性てすとであh、脳のMnレベルの有意な増加がMnのみを与えているのに比較して、両方が加えられているラットで見られた。3ヶ月ほどの亜慢的なテストでは、何ら変化は見られなかった。しかし、テスト終了時にばく露されたラットのIn vivo調査では、ばく露していないラットと比較して大きな行動変化を表した。

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研究目的(著者による)

1) To study brain manganese (Mn) levels in rats with or without experimental manganese administration (2.88 mg Mn2+, applied at the start of the experiment) and with or without the exposure to electromagnetic field at the end of acute or longterm exposures.
2) To observe rats behaviour at the end of longterm exposures (after 12 weeks) with possible implication to manganese or electromagnetic field exposure.

詳細情報

Manganese has a neurotoxic potential as a result of professional (metalurgy) and nonprofessional (traffic) exposure, when in excess in the brain.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: continuous for 30 min
acute exposure
ばく露2: 900 MHz
ばく露時間: repeated daily exposure, 30 min/day for 6 or 12 weeks
subchronic exposure

General information

Four groups of rats per test (acute or subchronic) were treated as follows: no exposure, exposure to inorganic manganese (Mn), exposure to EMF, and exposure to EMF + Mn. Inorganic manganese compound (MnSO4*4H2O) was applied at the start of the experiment by intratracheal instillation.

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 30 min
Additional information acute exposure
Modulation
Modulation type unspecified
ばく露装置
ばく露の発生源/構造
  • radiator simulating mobile phone
Distance between exposed object and exposure source 5 cm
ばく露装置の詳細 Rats were placed in Plexiglas tubes with only the head part sticking out. The antenna was located at a distance of 5 cm from the head of the rat.
パラメータ
測定量 種別 Method Mass 備考
電力 1 W unspecified 指定なし - -

ばく露2

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure, 30 min/day for 6 or 12 weeks
Additional information subchronic exposure
Modulation
Modulation type unspecified
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
電力 1 W unspecified 指定なし - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In acute test, significant increase in brain manganese level was found in rats exposed to both factors (electromagnetic fields and manganese) as compared to Mn administration only.
Within subchronic test such interaction did not appear, but in vivo observation of exposed rats (exposure to Mn and/or electromagnetic field) at the end of the test have demonstrated signficant behavioral changes as compared to unexposed animals.

研究の種別:

研究助成

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