Study type: Medical/biological study (experimental study)

Micronucleus frequency and cell proliferation in human lymphocytes exposed to 50 Hz sinusoidal magnetic fields. med./bio.

Published in: Health Phys 1999; 76 (3): 244-250

Aim of study (acc. to author)

The effects of 50 Hz sinusoidal magnetic fields on micronucleus induction and cell proliferation in human lymphocytes should be examined.

Background/further details

Peripheral lymphocytes were obtained from blood samples of 42 healthy donors aged between 26 and 54 years.

Endpoint

Exposure

General information

blood samples were divided into five groups and treated with: a) 0.05 mT b) 0.25 mT c) 0.5 mT d) 0.75 mT e) 1.0 mT or sham exposed

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 72 h
Exposure setup
Exposure source
Setup H.-coil pair, 21cm diameter, 80 turns (double wrapped) of 2 mm copper wire; coils horizontally in incubator; Plexiglas layer in middle of coil structure hosted samples
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0.05 mT effective value measured - -
magnetic flux density 0.25 mT effective value measured - -
magnetic flux density 0.5 mT effective value measured - -
magnetic flux density 0.75 mT effective value measured - -
magnetic flux density 1 mT effective value measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No statistically significant differences were observed in spontaneous micronucleus induction.
A slight variation in the proliferation index was found: increased cell proliferation at 1 mT magnetic flux density, and decreased at magnetic flux density of 0.05 mT. The effect was small, but statistically significant.

Study character:

Study funded by

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