The experiment was carried out with healthy adult female Wistar rats (eight weeks of age, with average body weight of 178±15 g).
The positive control consisted of animals treated with mitomycin C (2 mg/kg body weight).
Exposure duration: experiment 1: 4 h continuous; experiment 2: 4 h/day for 45 days
|magnetic flux density||1 mT||-||measured||-||+/- 0.05 mT|
The results concerning genotoxicity revealed no statistically significant differences between the negative control and the exposure groups in chromosome aberrations. However, a statistically significant higher mean micronucleus frequency was observed in the long-term magnetic field exposed group compared to the negative control and acutely magnetic field exposed group.
The mitotic index in bone marrow of both magnetic field exposed groups was significantly decreased when compared to that in the negative control. Additionally, bone marrow cytotoxicity (depression) was indicated by a significant lower ratio of polychromatic erythrocytes to normochromatic erythrocytes in both magnetic field exposed groups.
These results indicate that the exposure to extremely low frequency magnetic field may be genotoxic and cytotoxic on bone marrow cells of mammals.