Three peripheral blood samples from a healthy, nonsmoking, 23 years old man were utilized. Each experiment was done in triplicate. The cell cultures were exposed to different magnetic flux densities (1 mT, 1.5 mT, 2 mT), co-exposed (2 mT plus mitomycin C), only mitomycin C treated (positive control), and not exposed (negative control).
the following four experiments were carried out: i) exposure to 1.0 mT magnetic field ii) exposure to 1.5 mT magnetic field iii) exposure to 2.0 mT magnetic field iv) ii) exposure to 2.0 mT magnetic field plus Mitomycin-C
No statistically significant difference in sister chromatid exchange was observed in any exposure group.
The cell proliferation was increased in all exposure groups. The co-exposed cultures revealed a higher proliferation index compared to only mitomycin C treated cultures.
A higher mitotic index was found in all exposure groups. Co-exposed cells showed a higher mitotic index than only mitomycin C treated cells, but lower mitotic index than the negative control.
The data suggest that a magnetic field may modify the cell proliferation of human lymphocytes and decrease the cell proliferation inhibition of mitomycin C.