Study type: Medical/biological study (experimental study)

Combined exposure to extremely low frequency (ELF) magnetic fields and chemical mutagens: Lack of genotoxic effects in human lymphocytes med./bio.

Published in: Electro Magnetobiol 2001; 20 (3): 331-341

Aim of study (acc. to author)

This study was conducted to investigate the induction of genotoxic and cytotoxic effects in human lymphocytes in vitro following co-exposure to 50 Hz sinusoidal magnetic field and chemical mutagen.

Background/further details

Blood samples were taken from 10 healthy, non-smoking volunteers, aged between 27 to 58 years. Applied chemical mutagens were mitomycin C (25 and 50 ng/ml) and hydroquinone (60 µM).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure setup
Exposure source
Chamber Incubator
Setup Plexiglas layer in middle of coil structure hosted the samples in cylindrical culture flasks (10 cm diameter, 4 cm high).
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT effective value measured - -

Reference articles

  • Scarfi MR et al. (1999): Micronucleus frequency and cell proliferation in human lymphocytes exposed to 50 Hz sinusoidal magnetic fields.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The exposure to magnetic field alone did not affect the micronucleus incidence, but a slight increase in cell proliferation could be observed.
Co-exposure did not increase the damage due to the chemical treatments alone, both in the terms of genotoxicity (micronuclei formation) and cell proliferation.

Study character:

Study funded by

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