Study type: Medical/biological study (experimental study)

Tumor necrosis factor alpha and interferon-gamma production by human peripheral blood mononuclear cells exposed in vitro to sinusoidal 50 Hz magnetic fields. med./bio.

Published in: Bioelectrochem Bioenerg 1997; 44 (1): 121-125

Aim of study (acc. to author)

To study the tumor necrosis factor alpha and interferon-gamma production by human peripheral blood mononuclear cells exposed in vitro to sinusoidal 50 Hz magnetic fields after stimulation by means of different inducers (phytohemagglutinin, ionomycin, monoclonal antibody OKT3).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Modulation type: CW
Exposure duration: 1, 2, or 3 days

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 1, 2, or 3 days
Modulation
Modulation type CW
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0.2 mT minimum measured - -
magnetic flux density 1 mT - measured - -
magnetic flux density 2 mT maximum measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No effects on interferon-gamma production were found, while a decrease in tumor necrosis factor alpha production by exposed cells is revealed in different experimental conditions: The effect was observed both with spontaneous and with mitogen-induced cytokine production, with different time of culture and exposure, with different magnetic flux densities, and with different kind of mitogens.

Study character:

Study funded by

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