This study investigated whether expression of genes related to cell death signal pathways are altered in murine brain cells by the exposure to a working Global System for Mobile Communication cell phone in vitro.
Modulation type: pulsed
Exposure duration: continuous for 2 h
|continuous for 2 h
|Cell cultures were plated in 2 ml of medium with 4 mm depth in 35-mm Petri dishes. For exposure, a mobile phone was placed on top with its antenna over the center and the cover of the dish removed.
|A sham exposure was conducted.
|The phone was either on (exposed) or standby (sham).
No parameters are specified for this exposure.
The exposure to radiofrequency irradiation from a cell phone leaded to up-regulation of eight genes (amongst others caspase-2, caspase-6) in both "on" and "stand-by" modes in neurons, but only in "on" mode in astrocytes. Additionally, astrocytes showed up-regulation of the bax gene, a gene which regulates signal transduction on mitochondrial level.
These data indicate that even short-term exposure to cell phone radiofrequency emissions can up-regulate elements of apoptotic signal pathways in cells derived from the brain, and that neurons seem to be more sensitive to this effect than astrocytes.