Study type: Medical/biological study (experimental study)

Effect of low-frequency electromagnetic field exposure on oocyte differentiation and follicular development. med./bio.

Published in: Adv Biomed Res 2014; 3: 76

Aim of study (acc. to author)

To investigate the effects of extremely low frequency magnetic fields on the oocyte differentiation and follicular development in mice.

Background/further details

Pregnant mice were divided into an exposure and a sham exposure group (n=15 per group). Exposure/sham exposure took place during the pregnancy. After delivery, half of the female pups of both groups were sacrificed, while the other half was kept under normal conditions (no exposure) and sacrificed when they reached adulthood.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 4 hours/day during pregnancy (21 days)

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 4 hours/day during pregnancy (21 days)
Exposure setup
Exposure source
  • not specified
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 3 mT - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Ovaries from exposed mice showed oocyte nests that were mostly broken and irregular arranged, while in the sham exposure group oocyte nests were intact and regularly arranged. Primordial follicles of mice from the exposure group were less developed than those from the sham exposure group and oocytes appeared to contain heterochromatin and were shrunken with vacuolated cytoplasm.
The authors conclude that extremely low frequency magnetic fields could influence the oocyte differentiation and follicular development in mice and that this may impair fertility.

Study character:

Study funded by

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