Study type: Medical/biological study (experimental study)

The effects of prenatal and postnatal exposure to electromagnetic field on rat ovarian tissue. med./bio.

Published in: Toxicol Ind Health 2020; 36 (12): 1010-1018

Aim of study (acc. to author)

The effects of prenatal and postnatal exposure of rats to a 50 Hz magnetic field on the ovarian structure and function should be investigated.

Background/further details

Pregnant rats were either exposed to the magnetic field or sham exposed (n=4 each) from the first day of pregnancy. A total of 12 pups from exposed mothers (exposure group) and 10 pups from sham exposed mothers (sham exposure group) were further exposed and sham exposed, respectively, after birth for 42 days. All pups were sacrificed and investigated then.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: from first day of pregnancy until postnatal day 42 for 4 h/day on 5 days/week

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration from first day of pregnancy until postnatal day 42 for 4 h/day on 5 days/week
Exposure setup
Exposure source
Exposure room plastic cages
Setup Helmholtz coil pair (95 cm in diameter); each coil was made of 320 turns of 2.5-mm copper wire mounted on a wooden frame; the distance between the coils was 33 cm; rats were kept in plastic cages placed between coils during exposure
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 3 mT - measured - -

Reference articles

  • Tayefi H et al. (2010): The effects of prenatal and neonatal exposure to electromagnetic fields on infant rat myocardium.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Follicle stimulating hormone and iNOS levels were significantly higher and the estradiol level was significantly lower in the exposure group compared to the sham exposure group. Moreover, in the exposure group, fibrosis, congestion, bleeding areas, and degeneration of follicle structures were observed in ovarian tissue.
The authors conclude that prenatal and postnatal exposure of rats to a 50 Hz magnetic field might impair the ovarian structure and function.

Study character:

Study funded by

Related articles