Study type: Medical/biological study (experimental study)

Effects of cell phone radiation on lipid peroxidation, glutathione and nitric oxide levels in mouse brain during epileptic seizure. med./bio.

Published in: J Chem Neuroanat 2016; 75 Pt B: 111-115

Aim of study (acc. to author)

The effects of exposure of mice to a 900 MHz electromagnetic field on oxidative stress in the brain during an epileptic seizure should be investigated.

Background/further details

Epileptic seizures were experimentally induced via intraperitoneal administration of 60 mg/kg body weight pentylenetetrazol (PTZ).
Mice were divided into the following groups (n=9 each): 1) 15 min EMF exposure + PTZ treatment + 30 min EMF exposure, 2) 30 min EMF exposure + PTZ treatment + 30 min EMF exposure and 3) sham exposure for 30 min + PTZ treatment + 30 min sham exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 15 minutes and 30 minutes
Exposure 2: 900 MHz
Exposure duration: continuous for 2 x 30 minutes

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 15 minutes and 30 minutes
Additional info GSM phone
Exposure setup
Exposure source
Chamber glass cage
Setup GSM dual-band mobile phone was used as exposure source; the phone was placed centrally 1 cm below the glass cage
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.301 W/kg spatial average calculated 10 g peak value in the head
SAR 0.367 W/kg spatial average calculated 10 g peak value in the trunk
electric field strength 14.31 V/m - measured - ± 3.3897 V/m
magnetic field strength 0.0386 A/m - measured - ± 0.012 V/m
power 0.25 W - - - antenna input power

Exposure 2

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 2 x 30 minutes
Additional info GSM phone
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.301 W/kg spatial average calculated 10 g peak value in the head
SAR 0.367 W/kg spatial average calculated 10 g peak value in the trunk
electric field strength 14.31 V/m - measured - ± 3.3897 V/m
magnetic field strength 0.0386 A/m - measured - ± 0.012 V/m
power 0.25 W - - - antenna input power

Reference articles

  • Lopresto V et al. (2007): Exposure setup to study potential adverse effects at GSM 1800 and UMTS frequencies on the auditory systems of rats.
  • Beard BB et al. (2006): Comparisons of computed mobile phone induced SAR in the SAM phantom to that in anatomically correct models of the human head.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Lipid peroxidation and the total nitric oxide level in the brain were significantly increased in both exposure groups (groups 1 and 2) compared to the sham exposure group (group 3). Moreover, glutathione levels were significantly lower in both exposure groups compared to the sham exposure group. However, no statistically significant differences were noted between the exposure groups.
The authors conclude that exposure of mice to a 900 MHz electromagnetic field might increase oxidative stress in the brain during an epileptic seizure.

Study character:

Study funded by

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