研究のタイプ: 医学/生物学の研究 (experimental study)

[アセチルコリンエステラーゼ活性に対する携帯電話マイクロ波の構造的および動力学的影響] med./bio.

Structural and kinetic effects of mobile phone microwaves on acetylcholinesterase activity.

掲載誌: Biophys Chem 2005; 113 (3): 245-253

この研究は、携帯電話放射インビトロばく露により、電気ウナギのアセチルコリンエステラーゼの水溶液の酵素活性が変化するか否かを調べた。ばく露には、実際に使用されている携帯電話を用い、同一の酵素水溶液を分割して、ばく露無しとばく露ありの場合を比較した。その結果、ばく露により、アセチルコリンエステラーゼの構造と生化学的特性への不可逆的影響が見られた、と報告している。

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研究目的(著者による)

To determine the influence of nonthermal exposure to dual band mobile phone irradiation on the structure and function of electric eel acetylcholinesterase (an important CNS enzyme).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 915–1,822 MHz
Modulation type: pulsed
ばく露時間: continuous from 1 to 50 min
  • 電界強度: 12 V/m maximum (decreasing from 12 to 1 V/m every min)
  • SAR: 0.51 W/kg unspecified (unspecified)

ばく露1

主たる特性
周波数 915–1,822 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous from 1 to 50 min
Modulation
Modulation type pulsed
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
  • dual-band
Distance between exposed object and exposure source 50 mm
ばく露装置の詳細 Aliquots of enzyme solution of identical volumes were placed into glass test tubes. One tube was wrapped in a single thin aluminium foil to screen RF radiation.
Additional information All experiments were carried out with the phone operating in receive mode being called from a remote phone. When the phone received a call, the emitted field intensity increased in the first 10 s to a maximum of 12 V/m before decreasing to a lower "standby asymptotic" value of 1 V/m. To change the exposition time from 1 to 50 min, the samples were gradually exposed to cycles of 60 sec each.
パラメータ
測定量 種別 Method Mass 備考
電界強度 12 V/m maximum 測定値 - decreasing from 12 to 1 V/m every min
SAR 0.51 W/kg unspecified 測定値 unspecified -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

The data provided evidence that in vitro simple exposure of an aqueous solution of electric eel acetylcholinesterase to cellular phone emission resulted in an irreversible monomerization of the protein accompanied by a significant change in the enzyme activity.
It is found that radiofrequency irradiation irreversibly affect the structural and biochemical characteristics of the enzyme. SR-SAXS (Synchroton radiation small-angle X-ray scattering) measurements provided data on the association of newly formed monomers into a soluble hydrogel. Jellification was confirmed by the variation of H1NMR relaxation times values. Further evidences of this process were revealed by ESEM (Environmental Scanning Electron Microscopy) observations.
Although these data cannot be used to conclude whether exposure to radiofrequency during the use of cellular phone can lead to any hazardous health effect, they may be a significant first step towards further verification of these effects on other ex vivo or in vivo biological systems.

研究の種別:

研究助成

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