研究のタイプ: 医学/生物学の研究 (experimental study)

[皮膚微小循環に対するどちらかの極性の静磁界の影響] med./bio.

Effects of a static magnetic field of either polarity on skin microcirculation.

掲載誌: Microvasc Res 2005; 69 (1-2): 24-27

この研究は、永久磁石のどちらかの極の局所的な静磁界が、安静時の皮膚血液灌流に影響するか否かをボランティア実験で調べた。被験者(n = 12)の非利き手の第2指および第4指の甲側皮膚皮膚血液灌流(SBF)をレーザードップラー法で測定した。どちらに指での実験においても、まず、両方の指に擬似磁石によるばく露を行い、次にネオジム磁石のN極およびS極によるばく露を交互に行なった。ばく露の強度は、その指の手掌部で4024 G、指の甲側のSBF測定点で879±52 Gであった。3通り(擬似、N極、S極)のばく露時間はそれぞれ15分で、各15分のうちの最後の5分間について平均したSBFをSBF値とした。結果として、指を変えて反復測定したSBF値をテスト変数に用いて、磁石の影響または磁極の影響を分散分析した結果、被験者間でSBFに大きなばらつきがあった;ばく露条件間でSBFに有意差はなかった(P = 0.705);また、SBFと指の間に、有意な交互作用が認められた(P = 0.396)。一方、3つのばく露時間におけるばく露を受ける指と受けない指の間でのSBFの差をテスト変数に用いることで被験者間の変動を低減させた結果、磁石ばく露に起因する有意な影響が示された(P = 0.016);この影響は、ばく露を受けた指の安静時SBFを減少させるもので、N極およびS極のどちらでの同様であった、と報告している。

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研究目的(著者による)

To investigate whether either pole of a local static magnetic field of a permanent magnet affects skin microcirculation.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
  • DC/static
ばく露時間: 15 min
  • 磁束密度: 402.8 mT (at the center of the magnet`s surface)
  • 磁束密度: 87.9 mT (± 5.2 mT; at the site of skin blood perfusion measurement)

ばく露1

主たる特性
周波数
  • DC/static
タイプ
  • magnetic field
ばく露時間 15 min
ばく露装置
ばく露の発生源/構造
  • commercial molybdenum magnet (25.4 mm diameter x 12.7 mm)
ばく露装置の詳細 All testing was done with subjects seated with their arms and hands resting on a padded surface attached to the chair. The top surface of the magnets were covered with soft Velcro material (used for thermal insulation) on which the fingers were resting.
Additional information For sham control non-magnetized pieces of the same dimensions as the magnet, were placed under the middle phalanges of the 2nd and 4th fingers during a 15-min control interval. Thereafter, both shams were removed and replaced with a sham for the 4th finger and an active magnet with either its North or South pole facing the skin of the 2nd finger. Selection of the pole to place during this interval was decided based on a coin flip. After 15 min of exposure, sham and magnet were removed and replaced with a second sham under the 4th finger and the magnet with the opposite polarity under the 2nd finger during a final 15-min interval. In six subjects, the North pole was placed during the second interval, and in six other subjects it was placed during the third interval.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 402.8 mT - 測定値 - at the center of the magnet`s surface
磁束密度 87.9 mT - 測定値 - ± 5.2 mT; at the site of skin blood perfusion measurement

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中

研究の主なアウトカム(著者による)

The results revealed a large variability in finger skin blood perfusion among subjects and no significant difference in skin blood flow between exposure conditions or any significant interaction between skin blood perfusion and finger.
Comparing skin blood perfusion of the magnet-exposed second finger compared to the sham-exposed fourth finger for each subject, exposure to magnet resulted in a reduction in 11 of 12 subjects. There was no significant difference between effects of north and south poles of the magnet.

研究の種別:

研究助成

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