研究のタイプ: 医学/生物学の研究 (experimental study)

[ガンを誘発する無線周波:トリガ要因としての細胞内カルシウムの恒常性変化] med./bio.

Radiofrequency-induced carcinogenesis: cellular calcium homeostasis changes as a triggering factor.

掲載誌: Int J Radiat Biol 2005; 81 (3): 205-209

この研究は、リン組織の発ガン性の特徴をマウスに対するRFの影響から調べることである。マウスは4カ月、1週間に1時間RFにばく露された。擬似ばく露対照群とした。ガンの進展を18カ月巻に渡って追跡した。対照マウスの最高寿命は24カ月であった。死亡した全マウスを臨床的に、組織学的に、発ガン現象の進展を調べ、量的な比較を年齢で調べた。ラジオカルシウムトレーサ法で、ばく露後1、24時間で細胞カルシウムの膜輸送へのRFの影響を調べた。2回目の実験で誘導された脂質も調査した。RFはリンパ球細胞侵入リンパ芽球腹水の形成、組織学的に異なったタイプの節外性腫瘍、早期死亡を引き起こした。このような結果として、RFにばく露されたマウスは、対照群よりも早く発ガン現象が誘発され、対照よりも様々に異なった形のがん形成がなされた。このプロセスに、細胞カルシウム恒常性と年齢に依存した胸腺の変化が、発がん過程に重要な要因となっているようだ。

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研究目的(著者による)

To study the effects of radiofrequency in a mice strain characterized by age-determined carcinogenesis of lymphatic tissues (to investigate the biological modifications underlying carcinogenesis).

詳細情報

The evolution of carcinogenesis was followed up to 18 months. The maximal life span of control animals was about 24 months and the principal characteristic of the mice is to develop spontaneous lymphoid tumours in the course of ageing.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 800 MHz
ばく露時間: repeated exposure for 1 hour per week for 4 months
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ばく露1

主たる特性
周波数 800 MHz
ばく露時間 repeated exposure for 1 hour per week for 4 months
Modulation
Modulation type unspecified
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
チャンバの詳細 The RF exposure was carried out in a cylindrical polypropylene chamber, the exterior walls of which were covered with 10 mg/cm² aluminium foil, except for the top central area of 4 cm in diameter where the phone was positioned.
ばく露装置の詳細 The antenna of the cellular phone was located in the centre of the chamber. The animals were free to move in a circular corridor 5 cm wide and with a 2 cm separation from the antenna.
Additional information Two experiments were performed: In the first one, the 20 animals were divided equally into sham and exposure groups. The animals from both of these groups were injected intramuscularly with 10 µl isotonic calcium chloride 1 hour prior to their respective exposure or sham exposure treatments. In the second experiment, 24 animals were divided equally into sham and exposure groups. The animals from both these groups were injected intraperitionally with 30 µmol calcium 30 min prior to the their respective sham or exposure treatments.
パラメータ

No parameters are specified for this exposure.

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 脳/腫瘍
  • principal organs (spleen, liver, lymph nodes, lung, kidney, glands)
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The data show that radiofrequency provoked an earlier general lymphocyte cell infiltration, formation of lymphoblastic ascites and extranodal tumours of different histological types, as well as an increased early mortality. The findings suggest that in exposed animals, carcinogenesis may be induced earlier and with different pathological forms than in control mice. The modifications in cellular calcium homeostasis and the age-determined thymus involution appear to be important factors involved in this carcinogenesis process.

研究の種別:

研究助成

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