研究のタイプ: 医学/生物学の研究 (experimental study)

[妊娠ラットの子宮胎盤機能に対する携帯電話周波数マイクロ波の非熱的影響] med./bio.

Nonthermal effects of mobile-phone frequency microwaves on uteroplacental functions in pregnant rats.

掲載誌: Reprod Toxicol 2003; 17 (3): 321-326

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研究目的(著者による)

To investigate the effects in pregnant rats exposed to non-thermal 915 MHz microwaves.

詳細情報

In six different treatment groups a total of 36 rats were examined: 1.) rats exposed to microwaves at 0.6 mW/cm2, 2.) rats exposed to microwaves at 3 mW/cm2, 3.) rats immersed in water at 38°C (induced the same colonic temperature increase as the group exposed to 0.6 mW/cm2 microwaves), 4.) rats immersed in water at 40°C (induced the same colonic temperature increase as the group exposed to 3 mW/cm2 microwaves), 5.) rats immersed in 34°C water (considered to be thermo-neutral), 6.) control rats.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 915 MHz
Modulation type: CW
ばく露時間: continuous for 90 min

ばく露1

主たる特性
周波数 915 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 90 min
Additional information Padilla JM, Bixby RR. Using Dewar flask calorimetry and rectal temperatures to determine the SARs of small rodents. USAFSAM-TP-86-3. TX, USA: Brooks AFB 1986.
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • magnetron, applicator (350 mm x 470 mm x 455 mm)
チャンバの詳細 The environment of the exposure facility was maintained at 21-23 °C and 50-60% humidity.
ばく露装置の詳細 Rats were placed individually into semi-cylindrical acrylic plastic holders (inner diameter 60 mm, length 170 mm, walls 5 mm) and exposed in the device described previously [Inaba et al., 1992]. Two holders were put into the applicator with their long axis oriented parallel to the electric field.
Additional information Rats were assigned to six groups: exposed to EMF at 0.6 or 3 mW/cm²; immersed in water at 38, 40 °C (inducing about the same increase in colonic temperature as the EMF) or at 34 °C (thermoneutral) or in a control group.
パラメータ
測定量 種別 Method Mass 備考
電力密度 0.6 mW/cm² - 測定値 - ±10%
SAR 0.4 W/kg - 測定値 whole body -
電力密度 3 mW/cm² - 測定値 - ±10%
SAR 2 W/kg - 測定値 whole body -

Reference articles

  • Inaba R et al. (1992): [生体アミンのラット脳内含有量に対するマイクロ波全身ばく露の影響]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

Significant differences in the utero-placental circulation and in the placental endocrine functions between pregnant rats immersed in water at 34 and 38°C were identified, but not between rats immersed at 38°C and those exposed to microwaves at 0.6 mW/cm2. By contrast, significant decreases in the utero-placental blood flow and estradiol level in rats exposed to microwaves at 3 mW/cm2 as compared with those immersed in water at 40°C were observed. Therefore, microwaves at exposure levels that increase core temperature by about 3.5°C seem likely to produce utero-placental dysfunctions through thermal and nonthermal actions.
The microwave exposure to 0.6 mW/cm2 and water immersion at 38°C reduced splenic natural killer cell activity, but microwaves at 3 mW/cm2 did not change splenic natural killer cell activity as compared to the group exposed to 34°C water immersion.
In conclusion, the exposure to microwaves at 0.6 mW/cm2 (maximum permissible exposure level recommended by ANSI) do not exert nonthermal effects on the utero-placental blood flow, blood estriol and progesterone level, and splenic natural killer cell activity.

研究の種別:

研究助成

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