この研究は、ラット脳電図（EEG）へのスコポラミン（アセチルコリン受容体拮抗薬）単独処理の影響、および超低周波で変調されたマイクロ波（約0.3 mW /cm2）への繰り返しばく露の影響を比較した。体性感覚皮質に植え込んだ炭素電極を用いて、自由行動中のラットの脳波を記録し、平均された周波数スペクトル（0.5-30 Hz）を評価した。ラットは、マイクロ波（915 MHz、4 Hzで振幅変調（矩形波）、パルス幅20 ms）への反復ばく露（3日、1日30分間）を受けた。その結果、超低周波変調マイクロ波へのばく露単独で、EEGの高周波リズム（18-30 Hz）が有意に増強された；このような影響は、擬似ばく露群および無ばく露対照群とどちらでも観察されなかった；マイクロ波ばく露群では、スコポラミン投与によるEEGの緩徐化が起きなかった（無ばく露群ではスコポラミン投与により緩徐化が現れた）；得られたデータは、超低周波変調マイクロ波への低レベルの反復ばく露が脳内のコリン作動性システムの活動を変化させる可能性を示唆する、と報告している。
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To compare in the EEG of rats the effects of scopolamine (0.1 mg/kg) alone and after repeated exposure to low level microwaves modulated at extremely low frequency.
Scopolamine is an acetylcholine receptor antagonist.
A day before the first microwave exposure and on the day after the last (third) one, control experiments (sham exposure) were performed on the same animals.
Modulation type: pulsed
ばく露時間: intermittent (1 min on/1 min off) for 3 x10 min with 10 min non-exposure between them per day for a total of 4 days (3 consecutive days, 1 day after application of scopolamine)
|ばく露時間||intermittent (1 min on/1 min off) for 3 x10 min with 10 min non-exposure between them per day for a total of 4 days (3 consecutive days, 1 day after application of scopolamine)|
|Pulse width||20 ms|
|Repetition frequency||4 Hz|
|チャンバの詳細||The experimental box (Plexiglas, 15 x 17 x 30 cm) was placed in a MW anechoic (with pyramidal Eccosorb) electrically shielded chamber. All metallic parts and generators were located outside the chamber.|
|ばく露装置の詳細||A circular wire antenna (18 cm in diameter) fixed in horizontal plane at a distance of 25 cm above the animal was used. At that position of antenna, vertical direction and good homogeneity of MW field propagation was ensured. The MW currents in the antenna were supplied by a high-frequency generator tuned at 915 MHz, which in turn was operated by a low-frequency generator.|
|Additional information||Rats were irradiated intermittently (1-min field-on and 1-min field-off periods) during three 10-min sessions with a 10-min non-exposure between them. Rats were exposed to MW in 3 consecutive days (30 min/day). A day before the first MW exposure and on the day after the last (third) one, control (sham) experiments (the MW power was turned off) were performed on the same animals. Other rats were used in all 5-day sham sessions as a control for the MW exposure series. On the next day after the fifth session, experiments with physiological saline injection were performed on all animals. A day later, both the MW-exposed and sham-irradiated rats were randomly divided into two groups and given either scopolamine or physiological saline. Each injection was made 10 min before application of MW or sham exposure as above.|
|電力密度||0.3 mW/cm²||average over time||-||-||-|
The findings provide evidence that repeated low level exposure to extremely low frequency microwaves can modify an activity of cholinergic system in the brain.
Microwave exposure alone significantly enhanced the fast EEG rhythms (18-30 Hz) which was also observed in 10 minutes break periods between exposures. This effect was found neither in subsequent sham exposure experiment nor in irradiation-naive rats.
In the microwave-exposed animals, scopolamine did not cause a slowing in the EEG that was shown in non-exposed rats.