研究のタイプ: 医学/生物学の研究 (experimental study)

[低レベル超低周波変調マイクロ波へのばく露は、自由に動いているラットのベースラインとスコポラミンによる変調EEGに影響する] med./bio.

Repeated exposure to low-level extremely low frequency-modulated microwaves affects baseline and scopolamine-modified electroencephalograms in freely moving rats.

掲載誌: Int J Radiat Biol 2004; 80 (9): 691-698

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研究目的(著者による)

To compare in the EEG of rats the effects of scopolamine (0.1 mg/kg) alone and after repeated exposure to low level microwaves modulated at extremely low frequency.

詳細情報

Scopolamine is an acetylcholine receptor antagonist.
A day before the first microwave exposure and on the day after the last (third) one, control experiments (sham exposure) were performed on the same animals.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 915 MHz
Modulation type: pulsed
ばく露時間: intermittent (1 min on/1 min off) for 3 x10 min with 10 min non-exposure between them per day for a total of 4 days (3 consecutive days, 1 day after application of scopolamine)

ばく露1

主たる特性
周波数 915 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent (1 min on/1 min off) for 3 x10 min with 10 min non-exposure between them per day for a total of 4 days (3 consecutive days, 1 day after application of scopolamine)
Modulation
Modulation type pulsed
Pulse width 20 ms
Repetition frequency 4 Hz
Pulse type rectangular
ばく露装置
ばく露の発生源/構造
チャンバの詳細 The experimental box (Plexiglas, 15 x 17 x 30 cm) was placed in a MW anechoic (with pyramidal Eccosorb) electrically shielded chamber. All metallic parts and generators were located outside the chamber.
ばく露装置の詳細 A circular wire antenna (18 cm in diameter) fixed in horizontal plane at a distance of 25 cm above the animal was used. At that position of antenna, vertical direction and good homogeneity of MW field propagation was ensured. The MW currents in the antenna were supplied by a high-frequency generator tuned at 915 MHz, which in turn was operated by a low-frequency generator.
Additional information Rats were irradiated intermittently (1-min field-on and 1-min field-off periods) during three 10-min sessions with a 10-min non-exposure between them. Rats were exposed to MW in 3 consecutive days (30 min/day). A day before the first MW exposure and on the day after the last (third) one, control (sham) experiments (the MW power was turned off) were performed on the same animals. Other rats were used in all 5-day sham sessions as a control for the MW exposure series. On the next day after the fifth session, experiments with physiological saline injection were performed on all animals. A day later, both the MW-exposed and sham-irradiated rats were randomly divided into two groups and given either scopolamine or physiological saline. Each injection was made 10 min before application of MW or sham exposure as above.
パラメータ
測定量 種別 Method Mass 備考
電力密度 0.3 mW/cm² average over time - - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The findings provide evidence that repeated low level exposure to extremely low frequency microwaves can modify an activity of cholinergic system in the brain.
Microwave exposure alone significantly enhanced the fast EEG rhythms (18-30 Hz) which was also observed in 10 minutes break periods between exposures. This effect was found neither in subsequent sham exposure experiment nor in irradiation-naive rats.
In the microwave-exposed animals, scopolamine did not cause a slowing in the EEG that was shown in non-exposed rats.

研究の種別:

研究助成

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