研究のタイプ: 医学/生物学の研究 (experimental study)

[低レベルELF変調マイクロ波への反復ばく露は自由行動ラットの大脳皮質‐視床下部相互作用に影響を及ぼす:脳電図研究] med./bio.

Repeated exposure to low-level extremely low frequency-modulated microwaves affects cortex-hypothalamus interplay in freely moving rats: EEG study.

掲載誌: Int J Radiat Biol 2010; 86 (5): 376-383

この研究は、皮質及び視床下部背内側部に炭素電極を埋め込んだ10匹の自由行動ラットをI群(擬似ばく露超低周波変調マイクロ波(ELF-MW)の反復ばく露の混合ばく露:5匹)とII群(擬似ばく露:5匹)に分け、5日間連続で実験して、脳電図(EEG)の周波数帯毎の平均パワースペクトルを調べた。ELF-MW ばく露は、4Hz変調マイクロ波(915 MHzパルス幅20-ms、~0.3 mW/cm2)の間欠的(1分間「オン」、1分間「オフ」)な10分間ばく露平均SARは~0.7 mW/g)を基本単位として、実験1-2日目は2回(ばく露前、ばく露間、ばく露後の10分間を合わせて実験時間は50分間)、実験3-5日目は3回(同70分間)繰り返した。I群は10分間のELF-MW ばく露擬似ばく露をランダムに混合させ、II群は全て擬似ばく露とした。ELF-MW ばく露により、EEGの周波数帯毎の平均パワースペクトルの実験開始前のベースライン値に比較して、視床下部のベータ2帯のレベルが皮質のものより大きく上昇し、皮質視床下部間のベースライン値でのバイアスが消滅したことなどを報告している。

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研究目的(著者による)

To compare the effects of repeated exposure to extremely low frequency-modulated microwaves on cortical and hypothalamic electroencephalograms (EEGs) of freely moving rats.

詳細情報

The EEGs were recorded for five consecutive days either under sham exposures (five rats) or under mixed sham exposure/microwave exposures (five rats).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 915 MHz
Modulation type: FM, pulsed
ばく露時間: intermittently: 1 min on - 1 min off - for 10 min, 3 times per day for 3 days during a 5 day period (see "additional information")
  • 電力密度: 0.3 mW/cm² average over time (at a distance of 30 cm from the antenna)
  • SAR: 0.7 mW/g

ばく露1

主たる特性
周波数 915 MHz
タイプ
  • electromagnetic field
偏波
  • linear
ばく露時間 intermittently: 1 min on - 1 min off - for 10 min, 3 times per day for 3 days during a 5 day period (see "additional information")
Modulation
Modulation type FM, pulsed
Modulation frequency 4 Hz
Pulse width 20 ms
ばく露装置
ばく露の発生源/構造
  • circular wire antenna with a diameter of 18 cm
Distance between exposed object and exposure source 25 cm
ばく露装置の詳細 15 cm x 17 cm x 30 cm Plexiglas box placed in an anechoic chamber lined with pyramidal Eccosorb; antenna fixed in the horizontal plane outside and above the box
Sham exposure A sham exposure was conducted.
Additional information 10 min pre- and post-exposure periods exposure group: sham exposure on day 1 and day 4, MW exposure on days 2, 3 and 5 sham group: sham exposure on all five days remark of the EMF-Portal editor: exposure time was differently described in the method section, the figures and the results of this article
パラメータ
測定量 種別 Method Mass 備考
電力密度 0.3 mW/cm² average over time 測定値 - at a distance of 30 cm from the antenna
SAR 0.7 mW/g - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

Extremely low frequency-modulated microwaves increased beta wave2 activity (17.8-30.5 Hz) in both cortical and hypothalamic EEG. Moreover, a cumulative effect under repeated exposures to extremely low frequency-modulated microwaves was found.
In conclusion, the data are in line with evidence that repeated low-level exposure to extremely low frequency-modulated microwaves affects brain functioning and provide an additional approach when analysing underlying mechanisms.

研究の種別:

研究助成

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