研究のタイプ: 医学/生物学の研究 (experimental study)

[C3H/Bi雌マウスに対するパルス磁界の効果] med./bio.

Effect of a pulsed magnetic field on tumoral C3H/Bi female mice.

掲載誌: Cancer Biochem Biophys 1988; 10 (1): 59-66
Journal partially peer-reviewed/unclear

この研究は、雌のC3H / Biマウス(肺転移性を持つ、自然発生性でウイルス性の乳がんを発症する)の担がんマウス(n = 240)をばく露群と対照群に分け、ばく露群は、トロイダルパルス磁界(12Hz、100Hzまたは460Hz)のばく露を、10分間/日で3日/週、または1週間に1回30分間のばく露スケジュールで、がん出現の2−3週後から死亡するまで継続した。その結果、対照群と比較して、ばく露群の脾臓および肺の重量は少なかった;肺が軽量であることは肺転移の減少を意味するかもしれない;腫瘍の重量は、対照群に比べ、460Hz MF群では軽く、100Hz群では変化なく、12Hz群では重かったが、MFばく露によって寿命は変化しなかった、と報告している。

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研究目的(著者による)

To investigate the effects of 3 different pulsed magnetic fields (PMF) on tumoral mice.

詳細情報

A total of 240 mice were used in this study. 98 mice served as control. 75 mice were exposed to 460 Hz PMF, 35 mice to 100 Hz, and 32 mice to 12 Hz.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 12 Hz
Modulation type: pulsed
ばく露時間: from appearance of Tumor till death; 30 min/week or 10 min on 3 non-consecutive days of the week
ばく露2: 100 Hz
Modulation type: pulsed
ばく露時間: from appearance of Tumor till death; 30 min/week, 10 min on 3 non-consecutive days of the week or 30 min/day, 3 days per week
ばく露3: 460 Hz
Modulation type: pulsed
ばく露時間: from appearance of Tumor till death; 30 min/week; 10 min on 3 non-consecutive days of the week; 30 min/day, 3 days per week; 15 min, 2 days a week; 6 min 5 days a week; 30 min, 2 or 5 days a week

General information

89 mice were used as control, 75 were exposed to 460 Hz MF, 35 to 100 Hz MF and 32 to 12 Hz.

ばく露1

主たる特性
周波数 12 Hz
タイプ
  • magnetic field
波形
  • pulsed
ばく露時間 from appearance of Tumor till death; 30 min/week or 10 min on 3 non-consecutive days of the week
Modulation
Modulation type pulsed
Additional information

Toroidal pulsed magnetic field

ばく露装置
ばく露の発生源/構造
  • Magnobiopulse apparatus, magnetic field delivered by two applicators
チャンバの詳細 Exposure was performed in a container which was divided into compartments (29 mm x 29 mm x 100 mm); each compartment held one mouse. The applicators were placed on the top of the container exposing 10 mice at a time. Control mice were placed in the container in the same way as the exposed mice but in the absense of magnetic field.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 6 mT unspecified 指定なし - -

ばく露2

主たる特性
周波数 100 Hz
タイプ
  • magnetic field
波形
  • pulsed
ばく露時間 from appearance of Tumor till death; 30 min/week, 10 min on 3 non-consecutive days of the week or 30 min/day, 3 days per week
Modulation
Modulation type pulsed
Additional information

Toroidal pulsed magnetic field

ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 6 mT unspecified 指定なし - -

ばく露3

主たる特性
周波数 460 Hz
タイプ
  • magnetic field
波形
  • pulsed
ばく露時間 from appearance of Tumor till death; 30 min/week; 10 min on 3 non-consecutive days of the week; 30 min/day, 3 days per week; 15 min, 2 days a week; 6 min 5 days a week; 30 min, 2 or 5 days a week
Modulation
Modulation type pulsed
Additional information

Toroidal pulsed magnetic field

ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 6 mT unspecified 指定なし - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • lung, spleen
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No differences of mean life span were found between the groups. Mean tumor weight were found to be lighter in mice exposed to 460 Hz and higher in mice exposed to 12 Hz as compared with control. The exposed mice showed lighter lungs and spleens, compared with the control group.
The data may indicate a window frequency effect or suggest that higher frequencies inhibit growth.

研究の種別:

研究助成

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