研究のタイプ: 医学/生物学の研究 (experimental study)

[マイクロ波ばく露したマウスの骨髄細胞における姉妹染色分体交換の発生率] med./bio.

Incidence of sister chromatid exchange in bone marrow cells of the mouse following microwave exposure.

掲載誌: Radiat Res 1981; 85 (2): 340-348

この研究は、突然変異原および発がん物質細胞遺伝学的影響を最も敏感に検出する姉妹染色分体交換SCEアッセイを用いて、マイクロ波の潜在的な突然変異原性影響を調べた。マウスの骨髄細胞に、マイクロ波(2450MHz、入射電力密度20 mW/cm2、平均SAR21mW / g)のばく露を28日間与えた。ばく露群、擬似ばく露対照群、標準対照群でのSCE発生を比較した。結果として、ばく露群と対照群の間で、SCEの数に統計学的有意差は検出されなかった、と報告している。

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研究目的(著者による)

A sister chromatid exchange assay was utilized to investigate potential mutagenic bioeffects of microwave (2450 MHz) radiation on mouse bone marrow cells.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: CW
ばく露時間: 8 h/day for 28days
  • SAR: 15.6 mW/g minimum (whole body) (26.80 W/kg maximum value.)
  • 電力密度: 200 W/m² mean

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
波形
  • sinusoidal
ばく露時間 8 h/day for 28days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
チャンバの詳細 Environmental chamber lined with microwave absorber maintained at 22°C and 55 % humidity.
ばく露装置の詳細 Animals kept in 2.54 cm thick Styrofoam cages / 5 cm x 8 cm x 10 cm with the long axis of the cage and the animal parallel to electric field.
Additional information The cages were mounted in slots cut in a large Styrofoam sheet. The cages were located in a circular pattern and the animals were rotated around the circle of cages every 4 h. Control animals was kept in another enviromental chamber identical to the exposure chamber but the animals were not handled and remained in their home cages during the whole exposure period.
パラメータ
測定量 種別 Method Mass 備考
SAR 15.6 mW/g minimum 計算値 whole body 26.80 W/kg maximum value.
電力密度 200 W/m² mean 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

No statistically significant differences in the numbers of sister chromatid exchanges (SCEs) were detected between the exposed animals and the control mice.

研究の種別:

研究助成

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