研究のタイプ: 医学/生物学の研究 (experimental study)

[マイクロ波は疼痛緩和を誘導する:周波数依存性と外因性オピオイド] med./bio.

Electromagnetic millimeter wave induced hypoalgesia: frequency dependence and involvement of endogenous opioids.

掲載誌: Bioelectromagnetics 2008; 29 (4): 284-295

この研究は、マウスを用いて、ミリ波処置(MMWT)による疼痛緩和効果について実験的に調べた。マウスの鼻の領域に与えたMMWTのばく露パラメータは、周波数はミリ波治療に用いられる42.25、53.57、および61.22 GHz、入射電力密度は13.3 mW/cm2、ばく露時間は15分であった。疼痛緩和の評価は、(1)冷水テールフリックテスト(慢性神経因性疼痛モデル)、(2)ワイヤー表面テスト(坐骨神経の結紮により作成された慢性神経因性疼痛モデル)で行われた。その結果、MMWTによる疼痛緩和効果は周波数依存性が示され、61.22 GHzで最大の疼痛緩和効果が得られた;デルタおよびカッパオピオイド受容体の選択的ブロッカー、およびCNS組織における内因性オピオイドの直接ELISA計測を用いて、MMWTによる疼痛緩和を実験的に証明した、と報告している。

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研究目的(著者による)

This in vivo study was conducted to 1.) determine whether millimeter wave treatment induced hypoalgesia depends on the frequency of the millimeter wave and 2.) to define what types of opioid receptors are predominantly involved in the development of millimeter wave treatment induced hypoalgesia.

詳細情報

Male mice (18-20 g) were examined in two experimental models: 1.) the cold water tail-flick test (experimental model of chronic non-neuropathic pain), and 2.) the chronic constriction injury test (experimental model of chronic neuropathic pain following unilateral injury to the sciatic nerve).
Selective opioid receptor blockers (μ, δ, and κ receptor blockers) were used to define the types of opioid receptors which are involved in the development of the millimeter wave treatment induced hypoalgesia.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 42.25–61.22 GHz
ばく露時間: continuous for 15 min

ばく露1

主たる特性
周波数 42.25–61.22 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 15 min
ばく露装置
ばく露の発生源/構造
  • antenna
Distance between exposed object and exposure source 1 mm
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 13.3 mW/cm² - - - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The millimeter wave treatment statistically significantly decreased frequency dependent the level of both cold water induced pain and chronic neuropathic pain in mice. This effect was most pronounced when the frequency of 61.22 GHz was used.
The response to millimeter wave treatment was significantly decreased in mice which were pretreated with selective μ and δ receptor blockers. The concentration of the endogenous opioid enkephalin was significantly higher in midbrain and hypothalamus area.
These results indicate that the system of endogenous opioids seems to play an important role in the systemic effects of the millimeter wave treatment.

研究の種別:

研究助成

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