この研究は、ラットを用いた実験で、超低周波磁界（ELF-MF）の長期ばく露および両側卵巣摘出術（OVX）によって生じるホルモン変化が、下顎頭の組織学的および組織形態計測的な構造に与える影響を評価した。40匹の成熟した雌のSprague-Dawleyラットをランダムに4群に分けた（n = 10）。すなわち、対照群、OVX群、ELF-MF群、OVX + ELF-MF群である。ELF-MF（50 Hz、1.5 mT）ばく露は、1日4時間、6か月間実施した。すべての処置後、ラットの左の下顎頭を摘出して組織病理学的検査を行った。その結果、OVX群、ELF-MF群、OVX + ELF-MF群において、下顎頭での骨髄腔の不規則な外観など、いくつかの組織病理学的変化が観察された；OVX群では、肥大領域から骨化層への移行の乱れおよび石灰化の不規則な外観が見られた；OVX + ELF-MF群およびELF-MF群では、石灰化および骨化の領域に顕著な乱れと遅滞が見られたが、この2群間に、下顎頭軟骨層の厚さの有意差はなかった、と報告している。
The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →
To investigate whether histopathological changes of the mandibular condyle structure occur in ovariectomized rats exposed to extremely low frequency magnetic fields.
Female rats were divided into four groups (n=10 per group): 1.) control group, 2.) ovariectomy, 3.) exposure and 4.) ovariectomy + exposure.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
50 Hz
ばく露時間:
continuous for 4 h/day during 6 months
|
|
rats were divided into the following four groups: i) control ii) ovariectomy (sham exposure) iii) EMF exposure iv) ovariectomy + EMF exposure
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 4 h/day during 6 months |
| ばく露の発生源／構造 | |
|---|---|
| ばく露装置の詳細 | two pairs of Helmholtz coils with a diameter of 70 cm and 125 turns of insulated soft copper wire with a diameter of 1.5 mm, coils placed vertically at a distance of 47 cm inside a 130 cm x 65 cm x 80 cm Faraday cage; rats kept in 43 cm x 42 cm x 15 cm methacrylate boxes |
| Sham exposure | A sham exposure was conducted. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 1.5 mT | - | 測定値 | - | - |
In all experimental groups (groups 2-4), some histopathological changes such as irregular appearance in bone marrow cavities were observed, while the structure in the control group appeared normal. In the ovariectomized rats (groups 2 and 4), a loss in bone marrow was determined, while there was an increased amount of bone marrow in the rats exposed to magnetic field alone (group 3). In both magnetic field exposed groups (groups 3 and 4), a disruption and latency in the calcification and ossification was observed. However, no significant differences occurred in the thickness of the condylar cartilage layers between the groups.
The authors conclude that long-term exposure to extremely low frequency magnetic fields and the ovariectomy could induce histopathological changes in the rat's mandibular condyle. However, magnetic field exposure had no influence on the ovariectomy-induced changes.
このウェブサイトはクッキー（Cookies）を使って、最善のブラウジングエクスペリエンスを提供しています。あなたがこのウェブサイトを継続して使用することで、私たちがクッキーを使用することを許可することになります。
