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To investigate the effects of an extremely low frequency magnetic field exposure on the synaptic plasticity in the hippocampus of rats.
Three groups of rats were examined: 1.) magnetic field exposure (n=10), 2.) sham exposure (n=9) and 3.) cage control (n=10).
At the end of the exposure period, rats were anesthetized and a stimulating electrode and a recording electrode were inserted in the brain of the rats. Stimulation was performed using a stimulation protocol of 400 Hz (10 bursts of 20 stimuli, 0.2 ms duration).
ばく露時間: 2 hours/day for 3 month
|ばく露時間||2 hours/day for 3 month|
|ばく露装置の詳細||solenoid coil with length of 2 m, radius 20 cm and 100 turns/meter; diameter of copper wire 2 mm; adjustable resistance curcuit was connected to the power source to generate electric and magnetic field|
|Sham exposure||A sham exposure was conducted.|
In exposed rats, the excitatory postsynaptic potential slope and the compound action potential were significantly higher in comparison to the sham exposure and the cage control group. No significant differences were observed between the sham exposure and the cage control.
No significant difference in the paired-pulse ratio of the magnetic field exposed rats was observed before and after the stimulation.
The authors conclude that extremely low frequency magnetic fields may change the synaptic plasticity in the hippocampus of rats.