研究のタイプ: 医学/生物学の研究 (experimental study)

[無線周波電磁界の事前ばく露後に感染リスクが低下する非線形の適応現象] med./bio.

Non-linear adaptive phenomena which decrease the risk of infection after pre-exposure to radiofrequency radiation.

掲載誌: Dose Response 2014; 12 (2): 233-245

この研究は、無線周波電磁界GSM携帯電話電磁界)の事前ばく露により、大腸菌への抵抗性が変化するか否かを、ラットで実験した。(適応応答の)チャレンジドースの大腸菌を投与した時のマウスの生存率は、無線周波電磁界事前ばく露群は56%、事前ばく露なしの群では20%であった、と報告している。

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研究目的(著者による)

The effects of pre-exposure of mice to a radio frequency electromagnetic field on the survival rate after a bacterial infection should be investigated.
Remark EMF-Portal: This article presents the same data as a previous article (Mortazavi et al. 2012).

詳細情報

110 mice were divided into the following groups: 1) 2 h/day exposure to electromagnetic field and injection of Escherichia coli bacteria (n=10), 2) 2 h/day exposure and sham injection (saline solution) (n=5), 3) sham exposure and bacteria injection (n=5), 4) 4 h/day exposure and bacteria injection (n=10), 5) exposure and sham injection (n=5), 6) sham exposure and bacteria injection (n=5), 7) 8 h/day exposure and bacteria injection (n=10), 8) 8 h/day exposure and sham injection (n=5), 9) sham exposure and bacteria injection (n=5), 10) 12 h/day exposure and bacteria injection (n=10), 11) 12 h/day exposure and sham injection (n=5), 12) sham exposure and bacteria injection (n=5), 13) replication of group 10 (n=15), 14) replication of group 12 (n=15).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
ばく露時間: continuous for 2 hours/day for 3 days
  • SAR: 1.4 W/kg
ばく露2:
ばく露時間: continuous for 4 hours/day for 3 days
  • SAR: 1.4 W/kg
ばく露3:
ばく露時間: continuous for 8 hours/day for 3 days
  • SAR: 1.4 W/kg
ばく露4:
ばく露時間: continuous for 12 hours/day for 3 days
  • SAR: 1.4 W/kg

General information

background radiation was 0.1 µSv/h

ばく露1

主たる特性
周波数
タイプ
  • electromagnetic field
ばく露時間 continuous for 2 hours/day for 3 days
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
  • Nokia E71 GSM cell phone
Distance between exposed object and exposure source 5 cm
ばく露装置の詳細 cell phone was used in talk mode during exposure; mice were immobilized by placing their bodies in plastic restrainers; restrainers were placed around the antenna in a circular position
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.4 W/kg - - - -

ばく露2

主たる特性
周波数
タイプ
  • electromagnetic field
ばく露時間 continuous for 4 hours/day for 3 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.4 W/kg - - - -

ばく露3

主たる特性
周波数
タイプ
  • electromagnetic field
ばく露時間 continuous for 8 hours/day for 3 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.4 W/kg - - - -

ばく露4

主たる特性
周波数
タイプ
  • electromagnetic field
ばく露時間 continuous for 12 hours/day for 3 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.4 W/kg - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The results of the groups with sham injection of bacteria (2, 5, 8 and 11) were not presented or discussed.
Group 4 (4 h/day) showed no significantly different result in comparison to its corresponding sham exposure group (6) according to the authors, even though the associated p value of 0.046 would actually represent a significantly lower survival rate. (Remark EMF-Portal: However, as this value was relatively high, the authors spoke of a "borderline" p value, which they did not take into account.)
Group 13 (12 h/day) showed a significantly higher survival rate compared to its corresponding sham exposure group (14), as did the pooled results of groups 13 and 10 in comparison to the pooled results of groups 14 and 12.
The authors conclude that pre-exposure of mice to a radio frequency electromagnetic field might increase the survival rate after a bacterial infection. This could be the result of an adaptive response and activation of the immune system, what might be of potential therapeutic use.

研究の種別:

研究助成

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