研究のタイプ: 医学／生物学の研究 (experimental study)

[2450 MHzマイクロ波に対する乳腺腫瘍になりやすいマウスの慢性的、低レベル（1.0 W/kg）のばく露] med./bio.

Chronic, low-level (1.0 W/kg) exposure of mice prone to mammary cancer to 2450 MHz microwaves

著者: Frei MR, Jauchem JR, Dusch SJ, Merritt JH, Berger RE, Stedham MA
掲載誌: Radiat Res 1998; 150 (5): 568-576
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低レベル（0.3W/kg）、2450MHzのRF照射に長期間、乳腺腫瘍になりやすいマウスをばく露すると、腫瘍の発生、腫瘍発生の潜伏期間、腫瘍の成長速度、生存率などを擬似ばく露群と比較して、影響の無いことをこれまでの報告で示した（Frei et al., Bioelectromagentics 19, 20-31 (1998)）。新た恣意研究では、SARを1.0W/kgとして、同じ項目を調べた。100匹のC3H/HeJのマウスを円状導波管、2450MhzのRF放射に78週間（1日当たり20時間で1週間に7日）ばく露した。同時に100匹を擬似ばく露として用いた。触診で分かるような乳腺腫瘍の発生（擬似ばく露が30%、ばく露群が38%）、腫瘍発生の潜伏期間（擬似ばく露が62.0± 2.3週；ばく露群は62.5±2.2週）、腫瘍の成長などに違いは無かった。組織病理学的検査からも、悪性、転移性、良性の新生物の数に両群で違いがなかった。前回の実験結果も含め、0.3 1.0W/kgのSARでの2450MHzのRF照射は、マウスの乳腺腫瘍に対して何ら影響がない。

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研究目的（著者による）

To determine whether chronic, low-level exposure of mammary-tumor-prone mice to 2450 MHz radiofrequency radiation promotes an earlier onset (decreased latency), a greater total incidence, or a faster growth rate of mammary tumors.

詳細情報

The current study was designed to replicate a previous study (publication 3413) but to increase the SAR from 0.3 W/kg to 1.0 W/kg to determine if a threshold SAR effect exists.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: CW
ばく露時間: repeated daily exposure, 20 h/day, for 78 weeks
  • 電力: 140 mW mean (input power per waveguide)
  • SAR: 1 W/kg mean (whole body)

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
特性
  • guided field
偏波
  • circular
ばく露時間 repeated daily exposure, 20 h/day, for 78 weeks
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
チャンバの詳細 The waveguides were housed in a room (5.49 m square) maintained at 24 ± 1°C and 50 ± 5% humidity.
ばく露装置の詳細 The cages housing two mice were made of Plexiglas with 5-mm Plexiglas rods on the floor spaced 0.75 cm apart and oriented perpendicular to the individual waveguide (a copper mesh enclosure) [Guy et al., 1979]. They provided a floor area of 143 cm² per animal.
Sham exposure A sham exposure was conducted.
Additional information Mice were randomly assigned to RF and sham exposure groups (100 each).
パラメータ
測定量 値 種別 Method Mass 備考
電力 140 mW mean 測定値 - input power per waveguide
SAR 1 W/kg mean 測定値および計算値 whole body -
Additional parameter details

The ambient 60 Hz electric fields were negligible; the ambient magnetic fields were 0.13 µT (mean of 75 measurements ranging from 0.03 to 0.33 µT).

測定および計算の詳細

Transmitter output, forward, reflected, and absorbed powers were monitored and stored. As in the previous study, the waveguides were characterised by extensive dosimetric measurements using and comparing calorimetric and differential power techniques, both performed simultaneously using the same animals in the same positions.

Reference articles

  • Guy AW et al. (1979): [小動物のマイクロ波慢性ばく露に用いる円偏光2450 MHz導波管装置]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

The results indicate that under these experimental conditions, long-term, low-level exposure of mammary-tumor-prone mice to 2450 MHz radiofrequency did not affect mammary tumor incidence, latency to mammary tumor onset, mammary tumor growth rate, or survivorship when compared with sham-irradiated controls. Histopathological examination revealed no differences in numbers of malignant, metastatic, or benign neoplasms between the two groups.

研究の種別:

研究助成

Replicated studies

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