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Medizinische/biologische Studie (experimentelle Studie)

Effects of mobile phone type signals on calcium levels within human leukaemic T-cells (Jurkat cells).

[Wirkungen von Handy-typischen Signalen auf die Calcium-Gehalte innerhalb von menschlichen leukämischen T-Zellen (Jurkat Zellen)].

Veröffentlicht in: Int J Radiat Biol 2001; 77 (12): 1207-1217

Ziel der Studie (lt. Autor)

Es sollte untersucht werden, ob die Exposition in simulierten GSM-Mobilfunk-Signalen die Calcium-Konzentration oder den Calcium-Signalcharakter in einer menschlichen Lymphozyten-Zelllinie beeinflusst.

Endpunkt

Exposition/Befeldung (teilweise nur auf Englisch)

Exposition Parameter
Exposition 1: 915 MHz
Modulationsart: gepulst
Expositionsdauer: kontinuierlich für 10 min
  • SAR: 2,1 W/kg Maximum
  • SAR: 1,5 W/kg Mittelwert (gewichteter Durchschnittswert)
  • SAR: 1 W/kg Minimum
Exposition 2: 915 MHz
Modulationsart: CW
Expositionsdauer: kontinuierlich für 10 min
  • SAR: 2,1 W/kg Maximum
  • SAR: 1,5 W/kg Mittelwert (gewichteter Durchschnittswert)
  • SAR: 1 W/kg Minimum
Exposition 1
Hauptcharakteristika
Frequenz 915 MHz
Typ
Expositionsdauer kontinuierlich für 10 min
Modulation
Modulationsart gepulst
Tastgrad 12,5 %
Folgefrequenz 217 Hz
Expositionsaufbau
Expositionsquelle
  • modified coaxial line, see setup details
Kammer The RF exposure device was a modified coaxial line with a perfused cell chamber that was continuous with the inner conductor of the transmission line. The line was terminated in an electrical short consisting of a thin stainless steel shim. A round coverslip was inserted above the shim which also formed the floor of the cylindrical chamber. The cells were viewable through a small hole in the shim. The hole was small enough to provide shielding from electromagnetic scattering influence of the inverted microscope on which the RF exposure device was mounted.
Zusatzinfo Sham exposure took place under the same conditions and for the same amount of time.
Parameter
Messgröße Wert Typ Methode Masse Bemerkungen
SAR 2,1 W/kg Maximum gemessen - -
SAR 1,5 W/kg Mittelwert berechnet und gemessen - gewichteter Durchschnittswert
SAR 1 W/kg Minimum gemessen - -
Zusätzliche Parameterdetails
SAR was found to increase with radial distance from the centre of the hole. The SAR within the region of the examined cells varied between 1 and 2.1 W/kg, with a weighted average of 1.5 W/kg and a total error calculated to be ±1.2 dB.
Mess- und Berechnungsdetails
The electromagnetic exposure inside the cell chamber was determined by mathematical modelling using Multiple Multipole (MMP) software and verified against experimental measurement.
Exposition 2
Hauptcharakteristika
Frequenz 915 MHz
Typ
Expositionsdauer kontinuierlich für 10 min
Modulation
Modulationsart CW
Expositionsaufbau
Expositionsquelle
Parameter
Messgröße Wert Typ Methode Masse Bemerkungen
SAR 2,1 W/kg Maximum gemessen - -
SAR 1,5 W/kg Mittelwert berechnet und gemessen - gewichteter Durchschnittswert
SAR 1 W/kg Minimum gemessen - -
Zusätzliche Parameterdetails
SAR was found to increase with radial distance from the centre of the hole. The SAR within the region of the examined cells varied between 1 and 2.1 W/kg, with a weighted average of 1.5 W/kg and a total error calculated to be ±1.2 dB.
Exponiertes System:

Methoden Endpunkt/Messparameter/Methodik

Untersuchtes Material:
Untersuchungszeitpunkt:
  • nach der Befeldung

Hauptergebnis der Studie (lt. Autor)

Es gibt keinen Hinweis darauf, dass hochfrequente Emissionen von Handys mit Änderungen des Calcium-Levels oder der Calcium-Signalwirkung in Lymphozyten einhergehen.
Studienmerkmale:

Studie gefördert durch

  • Telstra Research Laboratories (TRL), Australia
  • Swinburne University Research and Development Fund, Australia

Themenverwandte Artikel

  • Cig B et al. (2015): Investigation of the effects of distance from sources on apoptosis, oxidative stress and cytosolic calcium accumulation via TRPV1 channels induced by mobile phones and Wi-Fi in breast cancer cells.
  • O'Connor RP et al. (2010): Exposure to GSM RF Fields Does Not Affect Calcium Homeostasis in Human Endothelial Cells, Rat Pheocromocytoma Cells or Rat Hippocampal Neurons.
  • Titushkin IA et al. (2009): Altered Calcium Dynamics Mediates P19-Derived Neuron-Like Cell Responses to Millimeter-Wave Radiation.
  • Rao VS et al. (2008): Nonthermal effects of radiofrequency-field exposure on calcium dynamics in stem cell-derived neuronal cells: elucidation of calcium pathways.
  • Platano D et al. (2007): Acute exposure to low-level CW and GSM-modulated 900 MHz radiofrequency does not affect Ba(2+) currents through voltage-gated calcium channels in rat cortical neurons.
  • Dutta SK et al. (1984): Microwave radiation-induced calcium ion efflux from human neuroblastoma cells in culture.