Es sollte untersucht werden, ob eine akute Exposition (2h) in hochfrequenten 1.9 GHz-Feldern (kontinuierliche Welle) primäre DNA-Schäden auslösen und/oder die Mikronukleus-Bildung in menschlichen Leukozyten-Kulturen induzieren könnte.
| Exposition | Parameter |
|---|---|
|
Exposition 1:
1,9 GHz
Modulationsart:
CW
Expositionsdauer:
kontinuierlich für 2 h
|
|
| Frequenz | 1,9 GHz |
|---|---|
| Typ | |
| Charakteristik |
|
| Polarisation |
|
| Expositionsdauer | kontinuierlich für 2 h |
| Modulationsart | CW |
|---|
| Expositionsquelle |
|
|---|---|
| Kammer | The waveguide applicators consisted of an aluminium tube, 110 mm in diameter and 210 mm long, which was shorted at one end and open at the other. They were fed from two identical excitation probes (monopoles, 33 mm long x 4 mm in diameter) spaced 90° apart and located 50 mm from the shorted end. All six waveguide applicators were housed in a wooden enclosure lined with MW absorbent foam. They were spaced 250 mm apart (center to center) and were separated by a shield consisting of a 200 mm x 300 mm aluminium sheet sandwiched between 6.4-mm thick absorber panels and extending 100 mm higher than the top of the sample dishes. |
| Aufbau | The sample holder located on the top of the open aperture of the waveguide consisted of two unequal-sized Petri dishes. The inner dish of 60 mm diameter containing the blood cell culture sat concentrically within the outer dish of 150 mm diameter on 3.2-mm plastic standoffs and was circulated by temperature-controlled coolant water maintaining the temperature in the culture at 37 ± 0.5°C. The coolant (130 ml) was kept at the same level as the sample (10 ml) for optimal SAR uniformity. |
| Schein-Exposition | Eine Schein-Exposition wurde durchgeführt. |
| Zusatzinfo | A total of five separate experiments were conducted over 3 months, each consisting of five RF-field exposed cultures and concurrent sham exposed, negative (incubator) and positive (1.5 Gy 137Cs γ radiation; at 0.987 Gy/min) controls. |
| Messgröße | Wert | Typ | Methode | Masse | Bemerkungen |
|---|---|---|---|---|---|
| SAR | 0,1 W/kg | Mittelwert | berechnet und gemessen | - | - |
| SAR | 0,26 W/kg | Mittelwert | berechnet und gemessen | - | - |
| SAR | 0,92 W/kg | Mittelwert | berechnet und gemessen | - | - |
| SAR | 2,4 W/kg | Mittelwert | berechnet und gemessen | - | - |
| SAR | 10 W/kg | Mittelwert | berechnet und gemessen | - | - |
Die Ergebnisse lieferten keinen Nachweis zur Unterstützung der Hypothese, dass eine akute, nicht thermische Exposition in hochfrequenten Feldern nennenswerte DNA-Schäden in menschlichen Leukozyten verursacht.
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