Study type: Medical/biological study (experimental study)

Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin. med./bio.

Published in: J Dermatol 2004; 31 (11): 878-883

Aim of study (acc. to author)

To study the effects of 900 MHz irradiation on fibrosis, lipid peroxidation, and anti-oxidant enzymes and the ameliorating effects of melatonin in rat skin.

Background/further details

The experimental groups were the control group, the exposed group, and the irradiated with melatonin treated group (received 10 mg/kg/day melatonin in tap water for 10 days before the irradiation). Skin graft was excized from the thoraco-abdominal area.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: CW
Exposure duration: repeated daily exposure, 30 min/day for 10 days

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration repeated daily exposure, 30 min/day for 10 days
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 5 mm
Setup The rats were placed in a plastic tube (5.5 cm in diameter, 12 cm long) that was placed above the dipole antenna.
Additional info Rats were allocated to three groups: control (sham exposed), irradiated (IR) and IR + Melatonin treated. The IR+Mel group received melatonin (10 mg/kg) in tap water daily before irradiation.
Parameters
Measurand Value Type Method Mass Remarks
power 2 W unspecified - - -
power density 1 mW/cm² unspecified measured - ± 0.4 mW/cm²

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Malondialdehyde and hydroxyproline levels and activities of catalase and glutathione peroxidase were increased significantly in the exposed group compared to the control group and decreased significantly in the irradiated + melatonin group. Superoxide dismutase activity was decreased significantly in the exposed animals and this decrease was not prevented by the melatonin treatment.
These data suggest that rats irradiated with 900 MHz suffer from increased fibrosis and lipid peroxidation. Melatonin treatment can reduce the fibrosis and lipid peroxidation caused by irradiation.

Study character:

Study funded by

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