Study type: Medical/biological study (experimental study)

Prevention of mobile phone induced skin tissue changes by melatonin in rat: an experimental study med./bio.

Published in: Toxicol Ind Health 2004; 20 (6-10): 133-139

Aim of study (acc. to author)

To study the effects the 900 MHz electromagnetic irradiation emitted by mobile phones on the induction of histopathologic changes in skin and the effect of melatonin on any of these changes.

Background/further details

The experimental groups were composed of a nontreated control group, an exposed group without melatonin and an irradiated with melatonin treatment group (received 10 mg/kg per day melatonin in tap water for 10 days before irradiation). Skin graft was excized from the thoraco-abdominal area.



Exposure Parameters
Exposure 1: 900 MHz
Modulation type: CW
Exposure duration: repeated daily exposure, 30 min/day for 10 days

Exposure 1

Main characteristics
Frequency 900 MHz
Exposure duration repeated daily exposure, 30 min/day for 10 days
Modulation type CW
Exposure setup
Exposure source
Setup The animals were kept individually in a round plastic tube cage (12 cm in length, 5.5 cm in diameter) which was ventilated from head to tail to decrease stress. The whole body of the animal was positioned in close contact above the dipole antenna.
Additional info The animals were divided into three groups (n=10/group): sham exposed group, 900 MHz irradiation (IR) group and melatonin and IR treated group (IR+MEL). Prior to the irradiation,10 mg/kg melatonin was given daily in tap water for 10 days to the IR+MEL group.
Measurand Value Type Method Mass Remarks
SAR 2 W/kg peak value unspecified - -
power density 1 mW/cm² mean measured - ± 0.04 mW/cm²

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In the exposed group, increased thickness of stratum corneum, papillamatosis, atrophy of epidermis, basal cell proliferation, increased granular cell layer (hypergranulosis) in epidermis and capillary proliferation, impairment in collagen tissue distribution and separation of collagen bundles in dermis were all revealed compared to the control group. Most of these changes, except hypergranulosis, were prevented with melatonin treatment.
In conclusion, exposure to 900 MHz irradiation caused mild skin changes. Furthermore, melatonin treatment can reduce these alterations and may have a beneficial effect to prevent 900 MHz mobile phone-induced rat skin changes.

Study character:

Study funded by

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