Study type: Medical/biological study (experimental study)

Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: protection by melatonin. med./bio.

Published in: Arch Med Res 2005; 36 (4): 350-355

Aim of study (acc. to author)

To examine 900 MHz mobile phone-induced oxidative stress that promotes production of reactive oxygen species (ROS) on renal tubular damage and the role of melatonin (a potent free radical scavenger and antioxidant agent) on kidney tissue against possible oxidative damage.

Background/further details

Melatonin was injected daily at 17 h with a dose of 100 µg/kg (before exposure).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: CW
Exposure duration: repeated daily exposure, 30 min/day for 10 days

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration repeated daily exposure, 30 min/day for 10 days
Modulation
Modulation type CW
Exposure setup
Exposure source
Chamber The exposure system consisted of a ventilated plastic tube cage (12 cm long x 5.5 cm in diameter) and a dipole antenna.
Setup The whole body of the rat was positioned in close contact above the antenna.
Additional info Animals were allocated to three groups: sham exposed, EMR exposed, and EMR exposed + melatonin treated. Melatonin dissolved in ethanol/saline was injected s.c. daily immediately before exposure. Sham exposed rats received isotonic saline solution instead. Rats were anesthetized with sodium pentobarbital.
Parameters
Measurand Value Type Method Mass Remarks
power 2 W peak value - - -
power density 1.04 mW/cm² mean measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In the exposed group, while tissue malondialdehyde and urine N-acetyl-beta-d-glucosaminidase levels increased, superoxide dismutase, catalase, and glutathione peroxidase activities were reduced. Melatonin treatment reversed these effects as well.
These data demonstrated the role of oxidative mechanism induced by 900 MHz mobile phone exposure, and melatonin, via its free radical scavenger and antioxidant properties, ameliorated oxidative tissue injury in rat kidney. These results show that melatonin may exhibit a protective effect on mobile phone-induced renal impairment.

Study character:

Study funded by

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