Study type: Medical/biological study (experimental study)

The effects of exposure to electromagnetic field on rat myocardium. med./bio.

Published in: Toxicol Ind Health 2013; 29 (5): 418-425

Aim of study (acc. to author)

To study the effects of electromagnetic fields on heart tissue in adult rats by biochemical and histomorphological evaluations.

Background/further details

28 rats were divided into an exposure group (n=14) and a sham exposure group (n=14).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous 4 h/day, 7 days/week for 2 months

General information

28 rats divided into exposed (n=14) and sham exposed (n=14) group

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration continuous 4 h/day, 7 days/week for 2 months
Exposure setup
Exposure source
Chamber rats were placed in polycarbonate cages between the two coils
Setup a pair of Helmholtz coils (diameter of 95 cm), each with 320 turns of 2.5 mm copper wire mounted on a wooden frame; distance between the coils was 33 cm
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 3 mT - measured - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In the exposed group, levels of lipid peroxidation significantly increased and enzyme activities of superoxide dismutase and glutathione peroxidase decreased compared with the sham exposed group.
The number of TUNEL-positive cells and caspase-3 immunoreactivity increased in the exposed rats compared with the sham exposed animals.
Electron microscopy revealed mitochondrial degeneration, reduction in myofibrils, dilated sarcoplasmic reticulum and perinuclear vacuolization in the exposed rats.
In conclusion, the data showed that the magnetic field exposure caused oxidative stress, apoptosis and morphologic damage in the myocardium of adult rats. The magnetic field-related changes could be the result of increased oxidative stress.

Study character:

Study funded by

Related articles