Study type: Medical/biological study (experimental study)

Effects of continuous and intermittent magnetic fields on oxidative parameters in vivo. med./bio.

Published in: Neurochem Res 2009; 34 (2): 238-243

Aim of study (acc. to author)

To study the effects of continuous and intermittent magnetic field exposure of 50 Hz (1.5 mT) on plasma, brain and liver tissues by using different biochemical parameters.

Background/further details

18 male guinea pigs were divided into three groups: Group I (control group), II (continuous exposure, 4 h/day), III (intermittent exposure, 2h on - 2 h off - 2 h on).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 4 h/day on 4 days
Exposure 2: 50 Hz
Exposure duration: intermittent 2 h on - 2 h off - 2 h on - on 4 days

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration continuous for 4 h/day on 4 days
Exposure setup
Exposure source
Setup Helmholtz coil with a diameter of 42.75 cm and 154 turns of insulated copper wire; plexiglas animal cage placed at the center of the coil
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT - measured - -

Exposure 2

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration intermittent 2 h on - 2 h off - 2 h on - on 4 days
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

While intermittent magnetic field exposure was effective on plasma lipid peroxidation (increase of plasma malondialdehyde), the continuous magnetic field induced an increase in plasma myeloperoxidase enzyme activity and nitric oxide levels. There was no effect of any exposure on the content of sulfhydryl groups.
Brain malondialdehyde levels were decreased in both exposure groups compared to the control group. Glutathione level in the brain was decreased under intermittent exposure and increased under continuous exposure. Brain myeloperoxidase enzyme activity increased after intermittent exposure.
An increase of the lipid peroxidation was observed in liver tissue both with intermittent and continuous magnetic field exposure. Liver myeloperoxidase enzyme activity was decreased in both exposure groups.
The data indicate that both the intermittent and the continuous magnetic field exposure affect various tissues in a distinct manner because of the different tissue antioxidant status and responses.

Study character:

Study funded by

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